Efficacy of Sildenafil therapy in Paediatrics & Neonates with Pulmonary Artery Hypertension– A study from a Tertiary Care University Hospital
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 3
Abstract
Background: Sildenafil citrate is one of the predominant drugs for treatment of paediatric and neonatal pulmonary artery hypertension (PAH). But there is an uncertainty in the current treatment pattern of sildenafil in children below 8kg body weight. Methodology: 43 paediatric and neonatal patients treated with sildenafil citrate for PAH were categorised based on their age and evaluated for the safety and the efficacy of sildenafil therapy. Patient demographics, pulmonary artery pressure, echocardiographic reports, drug therapy, adverse effects, World Health Organisation/New York Heart Association (WHO/NYHA) functional class and outcomes were noted. Adverse drug reactions were assessed using WHO & Naranjo’s causality assessment scales. Wilcoxon test was used for the comparison of WHO functional class & PAH pre and post sildenafil therapy. A p value of ≤ 0.05 was considered significant. Results: PAH associated with congenital systemic to pulmonary shunts (70%) was the major diagnosis observed. There was a significant improvement in the WHO/NYHA functional class pre and post sildenafil therapy from diagnosis Vs discharge (p < 0.001), diagnosis Vs first review phase (p < 0.001) and the discharge Vs review phase (p= 0.008). There were 36 patients with stable and satisfactory outcome, 2 with stable but not satisfactory outcome. 5 patients had unstable and deteriorating outcome resulting in death and the WHO & Naranjo’s causality assessments of these cases were unlikely. No side effects to sildenafil therapy were reported. Conclusion: In this study the sildenafil doses used were lower than new recommendations and the patients achieved stable and satisfactory outcome.
Authors and Affiliations
Anas. A, G. Kannan, R. Jebaraj, Vanitha Rani N
Keywords
Related Articles
- EP ID EP39800
- DOI -
- Views 259
- Downloads 0
Incidences and clinical outcomes of acute kidney injury in PICU: A prospective observational study
Introduction: Acute Kidney injury (AKI) is a common and a serious complication among patients admitted to the PICU. The incidence and outcome of AKI in PICUs is largely unknown hence this study was done to evaluate the...
Parasitic Leiomyoma: A Diagnostics Dilemma- A Case Report
Uterine leiomyomas (Fibroids) are common tumour seen in reproductive age group of females. Leiomyoma may occur either intrauterine or extrauterine. Extrauterine are rarely seen may occurring in broad ligament, peritoneu...
Efficiency of ultrasound guided aspiration cytology in deep seated lesions - a diagnostic evaluation
Abstract:BACKGROUND: Deep seated lesions, in the body are always a source of confusion and chaos in clinical surgical practice. Accuracy of guided Fine Needle Aspiration Cytology is potentially efficient, when it is carr...
Stress Testing in Cervical Spondylosis: Effect of Head Up Tilt on Heart Rate Variability
Introduction: Cervical spondylosis (CS) is a degenerative disease of cervical spine carrying significant morbidity. Autonomic nervous system (ANS) maintains homeostasis of the internal environment by a complex integrati...
Dental stem cells: Emerging Future
Stem cells are clonogenic cells that are capable of self-renewal and multi-lineage differentiation. Dental stem cells are the highly proliferative cells that have the potential to differentiate into numerous cell types...