Efficacy of Synovial Fluid Analysis in Diagnosing Various Types of Arthritis, with Special Reference to Percutaneous Synovial Biopsy as a Diagnostic Tool
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 8
Abstract
Introduction: Arthritis, a common clinical occurrence of joints, is a very prevalent chronic disease in India and various parts of the world. It is estimated to affect 1% of world’s adult population.Biopsies of Synovial fluid are being done as an adjuvant technique to assist in the diagnosis of arthritis.It offers a non invasive method to diagnose any condition of the joint like traumatic, inflammatory or non-inflammatory. The aim of present study is to estimate the efficacy of percutaneous synovial membrane biopsy in diagnosing of various types of arthritis with synovial biopsy as a diagnostic tool. Material and methods: Percutaneous synovial biopsy along with synovial fluid analysis was studied in 50 enrolled cases of arthritis. The fluid was subjected to physical, biochemical and cytological analysis. Results: In this study, total of 50 cases were studied. Knee joint was the most commonly involved. It was seen in 65.8% of the cases. In this study males were predominant; the male to female ratio was 2.3:1. The mean age of males were 54.2+/-1.8 years and females were 54.7+/-1.5 years.There were 14 cases (28%) of rhaimatoid arthritis, 13 cases of tubercular arthritis. There were 20% cases (n=10) which constituted non specific synovitis.Clinicopathological correlation was seen in 34 out of 50 cases. As a diagnositic tool, synovial fluid biopsy offers a sensitivity of 85%, 100% specificity with positive predictive value of 100% and negative predictive value of 62%. Conclusion: Biopsy of synovial membrane helps in establishing the exact aetiology of arthritis. It is a useful adjunct for establishing diagnosis and hence can prevent indiscriminate use of NSAIDS. Levels of Rheumatoid factor and C-reactive protein can be accurately estimated. In our study Synovial fluid biopsy showed a sensitivity of 85%.
Authors and Affiliations
Susheel Kumar Pathak, Meeta Agnihotri
Keywords
Related Articles
- EP ID EP424809
- DOI -
- Views 97
- Downloads 0
Assessment of the Efficacy of a Score based System used for Assigning Various Specific Scores for Predicting Difficult Laparoscopic Cholecystectomy
Introduction: After its introduction in 1987, laparoscopic cholecystectomy (LC) brought a radical change in the treatment of patients with gallstones. Various studies have quoted that significant risk and complications h...
Detection and Quantification of Cytomegalovirus in Immunocompromised Patients
Introduction: CMV disease ranges from asymptomatic infection in immunocompetent people to severe and lifethreatening infections in neonates and immunocompromised patients. The present study was undertaken to study the se...
Epidural Steroid Injection in the Management of Patients with Subacute or Chronic Low Back Ache with Radiculopathy due to Herniated Disc
Introduction: Low back ache is the most common problem seen in orthopedic clinic. Low backache with lumbosacral radiculopathy remains the most challenging musculoskeletal problem for its therapeutic management. In around...
The Significance of Tzanck Smear in Evaluation of Vesiculo Bullous Skin Lesions in Correlation with Clinical Diagnosis - A Cross Sectional Study
Introduction: Cytology is a diagnostic tool used to investigate the characteristics of individual cells. Tzanck smear is a rapid, simple sensitive cytology technique that can be performed with minimal patient discomfort...
Assessment of Clinico-Radiological Correlation with CT Guided FNAC of different Lung Lesions: A Hospital based Study
Introduction: Fine-needle desire cytology (FNAC) is a basic, generally protected, fast, trustworthy strategy for the diagnosis of lung lesions, especially with the guide of computed axial tomography (CAT) scan. The prese...