Efficacy of tuberculin purified protein derivative (PPD) immunotherapy in the treatment of plane warts on face
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 1
Abstract
Background: Viral warts are caused by Human Papillomavirus (HPV). Immunotherapy is one of the recent treatment modality with variable success rate. We undertook prospective study to evaluate the efficacy and safety of immunotherapy using tuberculin PPD for treatment of plane warts on face. Material and Method: A total of 40 patients were enrolled in the study each having more than 15 lesions on face. Each patient received 2 tuberculin units (TU) of PPD intra-lesionally not exceeding a maximum of 10 TU during each session. A total of 4 sessions were given at 2 weekly interval and patients were followed up to 6 months after the last dose. Clinical assessment was done by photographic measurements at baseline, before each treatment session, 1 and 6 months after completion of treatment. Result: Twenty-six patients (65.75%) showed complete clearance after 4 sessions, 10 (25%) patients showed partial clearance and 4 patients (10%) showed no improvement. Recurrence was seen in 10% patients. Erythema and pain at site of injection were the common adverse effects. Conclusion: Tuberculin PPD immunotherapy was found to be effective and safe treatment modality for plane warts with minimal side effects.
Authors and Affiliations
Megha Pundir, Kishor Singh, Sanjay Kanodia
Keywords
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