EFFICACY, SAFETY AND QUALITY OF LIFE OUTCOMES OF PALONOSETRON, RAMOSETRON AND GRANISETRON AS A PART OF ANTIEMETIC THERAPY IN PREVENTION OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING- A RANDOMISED COMPARATIVE TRIAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 24
Abstract
BACKGROUND 5-HT3 receptor antagonists have potent antiemetic effect in chemotherapy induced nausea and vomiting. The present study was conducted to study and compare the efficacy and safety of ramosetron, palonosetron and granisetron in preventing acute and delayed nausea and vomiting in cancer patients receiving moderately emetogenic chemotherapy, and the impact of these drugs on daily living of these patients. MATERIALS AND METHODS It was an open label, randomised, prospective, comparative, parallel study. A total of 59 patients were enrolled in the study. They were divided into 3 groups: palonosetron (0.25mg i.v and 0.5mg orally daily; n=18) group, ramosetron (0.3 mg i.v and 0.1 mg orally daily; n=22) group, and granisetron (1mg i.v and 2mg orally daily; n=19). The drugs were given for 5 days after chemotherapy cycle. In addition, all the three groups received inj. dexamethasone (16mg) prior to chemotherapy and tab. domperidone 10mg orally before chemotherapy and 3 times daily till day 5. The incidence and severity of nausea and vomiting, use of rescue antiemetics and the impact on daily living were evaluated for 7 days. Emetic episodes were recorded on a diary on a daily basis and nausea was measured on a visual analogue scale. Complete response rates (no emesis and no need of rescue antiemetics) were measured as the primary end point. The quality of life outcomes were measured using the functional life index – emesis (FLIE) questionnaire. Safety was evaluated by monitoring the adverse drug reactions of the test drugs. RESULTS The complete response rate in ramosetron group (72.7% in acute; 68.2% in delayed) were numerically better than palonosetron (66.7%; 61.1%) and granisetron (42.1%; 36.8%). The results didn’t achieve statistical significance. The impact on daily living was numerically better in ramosetron than palonosetron and granisetron but the results didn’t show a statistical significance. All the three drugs were well tolerated. CONCLUSION All the three drugs were effective and well tolerated. However, ramosetron showed numerically better complete response rates and better quality of life outcomes as compared to palonosetron and granisetron.
Authors and Affiliations
Seema Gupta, Aman Sharma, Rahul Sharma, Dinesh Kumar, Nusrat Kreem Bhat, Vijay Khajuria
Keywords
Related Articles
- EP ID EP566990
- DOI 10.18410/jebmh/2018/380
- Views 74
- Downloads 0
A STUDY ON ASYMPTOMATIC CARDIAC CHANGES IN TYPE 2 DIABETES PATIENTS
INTRODUCTION: Majority of the time the patient of Diabetes presents with complications like Myocardial infarction, heart failure, being end stages of cardiovascular 2 disease associated with other macro and microvascular...
COMPARATIVE STUDY OF DEXMEDETOMIDINE AND MAGNESIUM SULPHATE AS AN ADJUVANT TO BUPIVACAINE IN SPINAL ANESTHESIA
spinal anaesthesia is a widely used simple anaesthethetic technique providing adequate analgesia and muscle relaxation. Search for an adjuvant providing satisfactory intra and post-operative analgesia is still continuing...
RIVES AND LICHTENSTEIN REPAIR IN INGUINAL HERNIA- A COMPARISON OF POSTOPERATIVE COMPLICATIONS TO KNOW WHETHER RIVES REPAIR IS AS SAFE AS THE GOLD STANDARD LICHTENSTEIN REPAIR
BACKGROUND Hernia repair surgeries underwent a lot of modifications over time. These modifications were an attempt to reduce the recurrence rate and post-operative complications. Current techniques for Inguinal hernia sh...
BILIARY STENT ACTING AS NIDUS FOR STONE FORMATION: A CASE REPORT
PRESENTATION OF CASE Obstruction of common bile duct due to a ‘Forgotten Stent’ with stone formation is a rare entity. Choledocholithiasis is evident in approximately 10–15% patients with gallstones, more commonly in sec...
A COMPARATIVE STUDY OF AGE BETWEEN RADIOLOGICAL EXAMINATION OF ELBOW JOINT AND BIRTH CERTIFICATES IN MALES
INTRODUCTION Assessment of age by radiological examination of ossification centers of bones is useful to solve several medicolegal and civil cases. Radiological examination plays a crucial role in sensitive cases where d...