Efficient Synthesis of β-Lactam-Containing α-Aminophosphonates Using Fumaric Acid as Mild Catalyst
Journal Title: Chemical Methodologies - Year 2018, Vol 4, Issue 4
Abstract
A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.
Authors and Affiliations
Vijaya Bhaskar Vangala, Hari Pati
Keywords
Related Articles
- EP ID EP381621
- DOI 10.22034/CHEMM.2018.66128
- Views 88
- Downloads 0
Green Synthesis of Benzimidazole Derivatives: an Overview on Green Chemistry and Its Applications
The chemical substances in our environment are rising day by day. Only some of them are degraded, but most of them are non-degradable. These non-degradable substances produce pollutions which cause instability, harm or d...
Water Purification Using Nanotechnology an Emerging Opportunities
The most important component for living beings on the earth is access to clean and safe drinking water. Globally, water scarcity is pervasive even in water rich areas as immense pressure has been created by the burgeonin...
Computational NQR−NBO Parameters and DFT Calculations of Ampicillin and Zwitterion (Monomer and Dimer Structures)
Density functional theory (DFT) was used to analyze the structure and Nuclear quadrupole coupling constants (NQCC), χ, and asymmetry parameters, η, of 14N nuclei have been calculated for the antimicrobialampicillin in mo...
Effect of Trimethoprim Inclusion Complexation with Cyclodextrins on its Antimicrobial Activity
The aim of present study is to highlight the effects of β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HBCD) and also the effect of their concentrations and methods of inclusion complexation on solubility and ant...
On The Characterization, Use and Wastewater Detoxification Potential of Pyrolyzed Moringaoleifera Pods and Shells PART B: Sorption Isotherm, Kinetic, and Thermodynamic study
In this study, previously estimated tannery effluent with high pollutant (Cr) load of 987 mg/L was detoxified using pyrolysed Moringaoleifera Pods(PMOP)and Shells (PMOS).A performance assessment of the gained and charact...