Efficient Synthesis of β-Lactam-Containing α-Aminophosphonates Using Fumaric Acid as Mild Catalyst
Journal Title: Chemical Methodologies - Year 2018, Vol 4, Issue 4
Abstract
A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.
Authors and Affiliations
Vijaya Bhaskar Vangala, Hari Pati
Keywords
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- EP ID EP381621
- DOI 10.22034/CHEMM.2018.66128
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