Effect of Methanol Extract of Swertia chirata on Various Cellular Components of Blood in Rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 8
Abstract
Background: Swertia chirata has been used for its medicinal purpose worldwide specifcally in developing countries. People believe that medicinal plants are safe and economical; However, unaware of their toxic effects. Hematological parameters are the essential tool to assess the degree of toxicity on cellular components of blood. Objective: The aim of this study is to evaluate the effect of Swertia chirata on hematological parameters in rats using an automated analyser. Methodology: Albino Wistar rats were randomly assigned into three groups of six rats each. Group 1 was control, while group 2 (LD) and group 3 (HD) received 250 mg/kg and 500 mg/kg body weight of extract respectively, orally once daily. Results: No signifcant difference was observed in the WBC count of extract treated groups(P>0.05). The HD group did not show any signifcant difference (P>0.05) in the RBC count, HCT, Hb, MCV, MCH, MCHC, RDW, platelet count, PDW, MPV, PLCR as compared to control and LD groups. Whereas, MCHC was decreased in the LD group (P<0.0001; P<0.05) as compared to the control and high dose groups respectively. The RDW in the LD group was signifcantly increased (P<0.005) as compared to the control group. The P-LCR and PDW of the LD group were signifcantly decreased (P<0.05) as compared to the control and HD groups. Conclusion: The oral administration of Swertia chirata at low dose increases RDW and decreases MCHC, P-LCR and PDW, while no signifcant difference was observed at high dose on different haematological parameters.
Authors and Affiliations
Muneeza Lodhi| Department of Pharmacology, College of Medicine, Ziauddin University, Karachi, Pakistan Corresponding e-mail: muneezalodhi25@gmail.com, Zahida Memon| Department of Pharmacology, College of Medicine, Ziauddin University, Karachi, Pakistan, Shehla Shaheen| Department of Pharmacology, College of Medicine, Ziauddin University, Karachi, Pakistan, Ambreen Wasim| Department of Research and Advocacy, Ziauddin University, Karachi, Pakistan
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