Elaeocarpus ganitrus: its beneficial antiparkinsonian effect in MPTP induced motor and non-motor impairments in mice
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 2
Abstract
Aim: Elaeocarpus ganitrus (Family: Elaeocarpaceae), has shown beneficial role in the treatment of depression, convulsions and asthma. This study was undertaken to evaluate the antiparkinson effect of E.ganitrus. Materials and methods: Swiss albino mice of either sex were divided into 06 groups (n =12). 1st group mice were given 0.5% carboxy methyl cellulose (orally), 2nd group were administered MPTP (2 doses, each dose 20 mg/kg at 2 hr. interval, i.p.). Whereas 3rd, 4th and 5th groups - were administered with E. ganitrus (100, 200, and 400 mg/kg/day, orally), respectively, along with MPTP. Group 6- received Levodopa (30mg/kg, i.p,) along with MPTP. To evaluate anti-Parkinson effect, hanging wire test, tardive dyskinesia test and elevated plus maze test were performed on the1st day and on 8th day. One way ANOVA followed by post-hoc Tukey test, with p<0.05 was considered statistical significant. Results: E.ganitrus (200 and 400 mg/kg, p.o.) was found to increase the hanging time significantly (p <0.001) in hanging wire test and significantly decreased (p <0.001) the Vacuous Chewing Movements (VCMs) in tardive dyskinesia test as compared to MPTP group. E.ganitrus (200 and 400 mg/kg, p.o.) was found to significantly increase (p <0.001) the no. of entries and time spent in open arm and significantly decreased the no. of entries and time spent in closed arm (p <0.001) compared to MPTP treated group. Conclusion: The results of the present study conclusively showed that E.ganitrus has beneficial effect in MPTP induced experimental model of Parkinson’s disease.
Authors and Affiliations
Harish . G. Bagewadi| Asst. Professor, Department of Pharmacology, MVJ Medical College & Research Hospital, Bangalore, India-56211, Chetan S Bhangale| Senior Resident, Department of Pharmacology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India-110095, Naresh Khanna| Professor, Department of Pharmacology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India- 110095
Keywords
Related Articles
- EP ID EP15330
- DOI -
- Views 324
- Downloads 14
In Silico Investigation of Rv Hypothetical Proteins of Virulent Strain Mycobacterium tuberculosis H37Rv
Tuberculosis is an universal health problem worldwide. In Iraq the problem is aggravated by drug resistance. In Silico studies usually pave the way for more investigations of the real problem .On the other hand Mycobac...
Preliminary morphological and anatomical study of Orthosiphon stamineus
This study focuses on the characterization of morphological and anatomical traits of Orthosiphon stamineus which belongs to the Lamiaceae family. Orthosiphon stamineus, better known as “Misai Kucing†or “cats whisk...
Preliminary study of the digestive effects of Chenopodium ambrosioides Linn. (Chenopodiaceae) leaves extracts in goats
The effects of the crude aqueous extract of Chenopodium ambrosioides leaves on food intake and digestibility were evaluated with twelve Sahelian goats weighing about 25 kg. Three experimental groups, each consisting of...
Fast dissolving tablets: a novel approach
An oral route of drug administration is the most popular route of administration. It have wide acceptance up to 50-60% of total dosage forms. Tablet is the most popular dosage forms existing today because of its conven...
Optimisaton techniques: a futuristic approach for formulating and processing of pharmaceuticals
Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator as it comprises of multiple objectives. The traditional method followed for years is not only expensive and time consuming...