Electrophysiological Profiling of Depression in the Elderly
Journal Title: Archives of Depression and Anxiety - Year 2016, Vol 2, Issue 2
Abstract
Frontostriatal system functioning has been proposed to underpin performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-related potentials (ERPs) were elicited during a classic two-tone auditory oddball task to compare the electrophysiological profiles of elderly people (N = 54; Mean age = 85.46 ± 6.21) diagnosed with clinical depression (n = 17), subthreshold depression (n = 25) or no depression (n = 12). The P200 results revealed higher amplitude and significantly longer latencies in depressed groups relative to non-depressed participants. Higher P300 amplitude, but shorter latencies, were observed in depressed relative to non-depressed participants. Findings are discussed in terms of cognitive information processing models of ERPs and the potential for non-cognitive factors to impact on the resulting electrophysiological profile.
Authors and Affiliations
Patterson Jenny L, Bruce Barber J, O’Connor Daniel W, Toukhsati Samia R
Keywords
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- EP ID EP334329
- DOI 10.17352/2455-5460.000012
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