Elevated lipoprotein (a) levels in hypertensive patients in southern part of Nigeria
Journal Title: Journal of Public Health and Development - Year 2024, Vol 22, Issue 2
Abstract
Hypertension is linked to an increased risk of cardiovascular disease and is the leading modifiable risk factor for morbidity and mortality globally. Lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular disease. It has been suggested that Lp (a) contributes to an increased risk for atherosclerosis in hypertensive patients. This study was to investigate the levels of Lp (a) in hypertensive patients and correlate them with other risk factors of cardiovascular disease. This was a hospital-based cross-sectional study conducted between October 2022 and December 2023 at the Delta State Central Hospital, Warri. Three hundred participants consisting of two hundred hypertensive and one hundred normotensive individuals were recruited for the study. The study used a structured interviewer-administered questionnaire to collect data, which was then analyzed using SPSS version 23. One hundred and fifteen (57.5%) hypertensives and fifteen (15%) normotensive controls had plasma concentrations of Lp (a) above 30 mg/dl. The Lp (a) levels in the hypertensives ranged from 5.2 – 89.0 mg/dl with a mean of 32.8 ± 16.6 mg/dl. The controls had a range of 1.1 – 63.2 mg/dl with a mean of 16.9 ± 13.9 mg/dl. The difference in mean Lp (a) levels was statistically significant (p <0.001). In the hypertensives, Lp (a) correlated positively with body weight (r = 0.522, p = 0.001), BMI (r = 0.553, p = 0.002) and waist circumference (r = 0.628, p = 0.001). In the hypertensive population, obesity was a stronger predictor of Lp (a) levels than the female gender (OR: 3.6, 95% CI: 1.4 – 9.8, p = 0.010) and (OR 9.3; 95% CI: 2.5 – 34.0, p = 0.001). Lp (a) levels were significantly higher in the hypertensive patients than in the normotensive controls. There was a positive correlation between Lp (a) and BMI and waist circumference in the hypertensive group. Obesity had a higher predictive value for the Lp (a) levels than the female gender. Periodic screening for serum Lp (a) in hypertensive patients could be very useful in assessing the risk of cardiovascular disease.
Authors and Affiliations
Augustine Onovuakpo Eguvbe, Thompson Onoriedeode Ologbo, Ufuoma Blessing Ofili, Ekata Agnes Oghenekaro.
Keywords
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- EP ID EP736622
- DOI 10.55131/jphd/2024/220219
- Views 54
- Downloads 1
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