Emergence of drug resistance of Acinetobacter at tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
BACKGROUND & OBJECTIVE Acinetobacter, although saprophytic, the emergence and spread of Acinetobacter in hospital environment is a major area of concern. . It has been associated with a wide variety of illnesses in hospitalized patients, especially patients in the intensive care units. These infections are often difficult to treat, because of the widespread antibiotic resistance. This study is conducted to know the prevalence and drug resistant pattern of Acinetobacter in tertiary care hospital. MATERIAL & METHODS 950 isolates of Acinetobacter were obtained from various clinical samples, and subjected to identification by different biochemical tests and antibiotic susceptibility testing by disc diffusion testing by Kirby Baurer method. RESULT Out of 950 isolates of Acinetobacter, 82% were Acinetobacter. calcoaceticus baumannii complex remained 18% were other Acinetobacter spp. Acinetobacter isolates were resistant to important groups of antibiotics tested, including amikacin (50%), gentamycin (65%), tobramycin (38%), ceftriaxone (92%), ceftazidime (80%), cefepime (88%), ampicillin-sulbactum (44%), piperacillin-tazobactum (38%),ciprofloxacin (81%) levofloxacin(82%), imipenem (10%) and trimethoprim-sulfamethoxazole (65%), meropenem (15%), polymixin B (2.2%), colistin (2%). CONCLUSION Early detection of MDR Acinetobacter and infection control practices are the best defense against these organisms. Rational use of antimicrobials is an important aspect to delay the emergence of XDR and PDR Acinetobacter spp.
Authors and Affiliations
Jethwa DK
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