Emphasizing the Contribution of Infectious Pathogenic Agents to the Diagnosis of Conjunctival Carcinomas
Journal Title: Ophthalmology and Vision Science - Year 2018, Vol 1, Issue 5
Abstract
Reports show that viruses and other microorganisms currently cause 20% of the human cancers in developed countries, while in developing countries it is over 30%. The course from pathogenic infection to tumor initiation is slow and may take years after primary infection. These infections may additionally involve epigenetic events and host factors, such as immunosuppression, somatic mutations, and genetic predisposition. Currently we have no vaccines for cancers of the eye, nor do we have effective therapeutic agents for these cancers. We have gaps that are a result of inadequate understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause ocular cancers, the mechanisms they exploit to cause the cancers, and how to interrupt progression to the cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies. Studies on pathogen-related cancers including some ocular cancers will lead to the identification of mechanisms relevant to oncogenesis as well as molecular markers for diagnostic/prognostic methods and targets for therapeutic strategies. Moreover the relevance of the molecular markers is their ability to inform on preventive strategies, which are always cost-effective and can usually be implemented with relatively modest investments.
Authors and Affiliations
Kenneth Simbiri
Keywords
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