Enalapril Confers Protective Effect on Isoproterenol-Induced Myocardial Infarction in Rats through Downregulation of Cardiac Troponin, C-reactive Protein, Upregulation of IL-10β as Well as Anti-Oxidant and Anti-inflammatory Activities
Journal Title: International Journal of Biochemistry Research & Review - Year 2017, Vol 20, Issue 3
Abstract
Myocardial infarction is an irreversible death of heart muscle secondary due to prolonged lack of oxygen supply. The present study was designed to evaluate the protective effect of enalapril in isoproterenol-induced myocardial infarction in rats using changes in haemodynamic, biochemical, histopathological and immunohistochemistry parameters. Twenty-one male Wistar rats divided into three groups were used where the control (group A) was administered for normal saline which continued for 7 days, group B animals received normal saline for 7 days and thereafter isoproterenol (ISO) at 85 mg/kg on day 8 and 9. Group C animals were pretreated with enalapril (10 mg/kg) for 7 days and thereafter received ISO on day 8 and 9. On day 10, the blood pressure change in the animals were measured and thereafter sacrificed by cervical dislocation. The heart of each rat was removed, homogenized and used to assay for some oxidative stress markers and some antioxidant parameters. In this study, ISO caused myocardial infarction as seen by significant decrease in systolic, diastolic and mean arterial pressure but was corrected by enalapril. Enalapril caused significant increase in the levels of SOD, GPx, GST and GSH but significant decrease in MDA content and H2O2 generation. But reverse was the case for group B animals. Immunohistochemistry showed that ISO caused higher expressions of cardiac C-reactive protein (CRP) and cardiac troponins 1 (CTn1) and decrease in IL-10β but vice-versa for enalapril. No histopathological changes were recorded for enalapril. The study thus showed that enalapril significantly exhibits cardioprotective effects.
Authors and Affiliations
B. O. Adeoye, T. O. Ajibade, E. R. Asenuga, O. A. Adejumobi, A. A. Oyagbemi
Keywords
Related Articles
- EP ID EP317069
- DOI 10.9734/IJBCRR/2017/38498
- Views 103
- Downloads 0
Biochemical and Haematological Profile in Patients with Alcohol Dependence Syndrome (ADS) Co-Morbid with Nicotine Dependence Syndrome (NDS)
Aims: To compare and assess the biochemical and haematological parameters in patients with Alcohol dependent syndrome (ADS) co-morbid with Nicotine dependent syndrome (NDS) in comparison to those with only Alcohol depend...
Formulation, Nutritional Evaluation and Consumer Acceptability of High Energy and Protein Dense Complimentary Foods from Millet and Soybeans
This study was designed to formulate complementary foods from millet and soybean blends with the aim to provide high energy and proteineous food for vulnerable populations. Single screw extruder was used for the extrusio...
Study of Genetic Diversity among Different Tomato (Lycopersicum esculentum Mill.) Lines through Morphological and Biochemical Analysis
Aims: The aims of this study were to characterize the existing genetic diversity from Azad Jammu & Kashmir and to identify some selectable markers based on total leaf protein profiles. The purpose of the investigation wa...
Weekly Occurrence of Gymnodinium catenatum and Paralytic Shellfish Poisoning in the Mediterranean Shore of Morocco
Weekly monitoring for the presence of Gymnodinium catenatum and PSP toxins in mussels (Mytilus galloprovinciallis) harvested on the growing site in Fnideq on the Mediterranean Moroccan coast was carried out from 2010 unt...
Carotenoid Levels, Total Phenolic Content and Antioxidant Activity Variations in Varieties of Citrullus lanatus under Storage at Room Temperature
Introduction: Non-communicable diseases (NCDs) are economically burdening and are globally projected to increase deaths upto 75% by 2030. With the cause partly attributed to unhealthy diets, the major contributing factor...