Endocannabinoid system protects against cryptogenic seizures.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 1
Abstract
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
Authors and Affiliations
Clementina van Rijn, Martin Perescis, Lyudmila Vinogradova, Gilles van Luijtelaar
Keywords
Related Articles
- EP ID EP119068
- DOI -
- Views 100
- Downloads 0
Activity of essential phospholipids (EPL) from soybean in liver diseases.
Essential phospholipids (EPL) contain a highly purified extract of polyenylphosphatidylcholine (PPC) molecules from soybean. The main active ingredient is 1,2-dilinoleoylphosphatidylcholine (DLPC), which differentiates i...
Comparison of the effects of valproic acid and levetiracetam on apoptosis in the human ovarian cancer cell line OVCAR-3.
Background: We have previously shown that due to its cytotoxic and cytostatic activities, valproic acid (VPA), but not levetiracetam (LEV), may have potential as a drug for treating human ovarian cancer. In the present s...
In vitro effects of CB(1) receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain.
The in vitro effects of arachidonyl-2-chloroethylamide (ACEA; a selective CB(1)-receptor agonist) and N-piperidin-l-yl)-5-(4-chlorophenyl)-1-(2,4-cochlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A; a selective...
Effects of bupropion on the reinstatement of nicotine-induced conditioned place preference by drug priming in rats.
Nicotine is one of the most widely consumed psychoactive drugs, and its consumption is currently associated with other drugs of abuse, such as opioids. The aim of the present study was to evaluate the efficacy of the aty...
Nicotine potentiates imipramine-induced effects on catecholamine metabolism: possible relation to antidepressant activity.
Following our behavioral studies demonstrating augmentation of imipramine action by concomitant administration of nicotine, we investigated the effects of one or 14 days of treatment (twice daily) with imipramine and nic...