Endocrine abnormalities in two siblings with Rothmund Thomson Syndrome
Journal Title: Annals of Clinical Endocrinology and Metabolism - Year 2018, Vol 2, Issue 1
Abstract
Rothmund-Thomson syndrome is a rare autosomal recessive disorder characterized by poikiloderma (skin atrophy, telangiectasia, hyper- and hypopigmentation), congenital skeletal abnormalities, short stature, premature aging, and increased risk of malignant disease. Two siblings with Rothmund-Thomson Syndrome showed the following characteristic features: severe growth failure, dystrophic nails, absent eyelashes/eyebrows, small hands, clinodactyly, microdontia and congential poikiloderma. In addition, delayed sexual development with cryptorchidism in the male and Hashimato thyroiditis in the female patient were detected. These cases are presented here because of these endocrine patterns, with the aim of drawing attention to the invisible aspects of Rothmund-Thomson syndrome.
Authors and Affiliations
Nagehan Aslan, Ozgur Pirgon
Keywords
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- EP ID EP559461
- DOI 10.29328/journal.acem.1001010
- Views 27
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Endocrine abnormalities in two siblings with Rothmund Thomson Syndrome
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