Endogenous Antioxidant Responses to Dietary Honey Supplementation in Alloxan induced Diabetic WistarRats
Journal Title: IOSR Journal of Nursing and health Science - Year 2018, Vol 7, Issue 6
Abstract
Background Dietary management has been a source of concern both to the diabetics and to their attending physicians. Cellular injury resulting from oxidative stress is implicated in the pathogenesis of diabetes and its complications. The aim of the present study was to determine the impacts of honey on the endogenous antioxidants of alloxan-induced diabetic wistarrats. Methods The study involved 32 male wistar rats separated into groups of 8. Diabetes mellitus was induced in eachanimal by intra-peritoneally injecting a single dose of 200mg/kg of 2% alloxan solution after an overnight fast and confirmed after 72 hours with plasma glucose ≥ 12.0mmol/l. Group 1 served as the diabetic control. Groups 2, 3 and 4 received 10ml/kg/day of 10%, 30% and 50% honey respectively. At the end of 8 weeks, blood samples were collected from the animals to determine the biomarkers of oxidative stress using standard methods. Results The results showed thatdietary supplementation of moderately diluted honey caused significant increases in serum glutathione and superoxide dismutase but no significant change in catalase of diabetic rats. Conclusion Honey supplementation in moderately diluted forms ameliorates alloxan induced oxidative stress by inducing the endogenous antioxidants. Therefore the blood glucose lowering and organo-protective effects of honey may be attributed to its anti-oxidative properties
Authors and Affiliations
Onyebuchi Obia, Asuquo E Asuquo
Keywords
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- EP ID EP437158
- DOI 10.9790/1959-0706053740.
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