Endogenous neuroprotective factors: neurosteroids.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 3
Abstract
Neurosteroids are a group of steroid hormones synthesized by the brain in the presence of steroidogenic enzymes. Specific neurosteroids modulate function of several receptors,and also regulate growth of neurons, myelinization and synaptogenesis in the central nervous system. Some neurosteroids have been shown to display neuroprotective properties, which may have important implications for their potential use in the treatment of various neuropathologies such as: age-dependent dementia, stroke, epilepsy, spinal cord injury, Alzheimer's disease (AD), Parkinson's disease (PD) and Niemann-Picktype C disease (NP-C). This paper focuses on neuroprotection afforded by neurosteroids.
Authors and Affiliations
Katarzyna Wojtal, Michał Trojnar, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP128792
- DOI -
- Views 110
- Downloads 0
Optimization of lidocaine application in tumescent local anesthesia.
Tumescent local anesthesia is based upon the infusion of large volumes of neutralized anesthetic solutions, mainly lidocaine, at very low concentrations. This results in the paralysis of sensory nerve endings and minute...
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.
It has been proposed that metformin exerts protective effects on ischemic hearts. In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in...
Effect of hydrochlorothiazide on the anticonvulsant action of antiepileptic drugs against maximal electroshock-induced seizures in mice.
Background: The purpose of this study was to evaluate the effect of hydrochlorothiazide (HCTZ), a thiazide-type diuretic and an antihypertensive drug, on the anticonvulsant activity of numerous antiepileptic drugs (AEDs:...
Free radicals generated by xanthine/xanthine oxidase system augment nitric oxide synthase (NOS) and cyclooxygenase (COX)-independent component of bradykinin-induced vasodilatation in the isolated guinea pig heart.
Recently, we have reported that bradykinin (Bk)-induced vasodilation was selectively potentiated by a low concentration of reactive oxygen species (ROS) generated by xanthine/xanthineoxidase system (XOX) in the coronary...
Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes.
Backround: Lomefloxacin is a potent bactericidal antibiotic. The use of this drug in treatment of various infections is accompanied by serious adverse effects on pigmented tissues. The exact mechanisms of lomefloxacin si...