Endometrial estrogen and progesterone receptors in infertility and abnormal uterine bleeding
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2018, Vol 3, Issue 1
Abstract
Introduction Evaluation of endometrial histology can be made more meaningful with the study of Estrogen and Progesterone receptor ER and PR status Present study aimed at studying ER and PR status of normal endometrium and endometrium in infertility and abnormal uterine bleeding and elucidating its relevance and utilityMaterials and Methods This case control study was carried out on prospectively registered patients It included 12 cases of infertility 24 cases of abnormal uterine bleeding 14 cases of uterine leiomyoma and 22 cases of age matched controls undergoing endometrial sampling for causes other than above mentioned conditions The cases were subjected to thorough clinical evaluation The study of endometrium was done with routine histology Endometrial ER and PR expression was studied immunohistochemically The data collected was analyzed to find out the variability of expression of endometrial ER and PR in normal and abnormal endometrium with studentrsquos ttest and correlation ttest SPSS software version 11Results The ER and PR expression in normal endometrium showed cyclical variation It was highest in the proliferative phase followed by the periovulatory phase followed by a significant decline in the late secretory phase In cases of infertility and abnormal uterine bleeding with endometrial dysfunction late secretory endometrium showed increased ER expression as compared to controlsConclusion Variations noted in endometrial ER and PR expression in infertility and abnormal uterine bleeding provided insight in its pathogenesis and helped in contemplating treatment optionsKeywords ER PR Endometrium Infertility Abnormal uterine bleeding Uterine leiomyoma
Authors and Affiliations
Vinanti Ajit Golwilkar, Meenal Vitthal Jadhav, Nalini Vinayak Kadgi
Keywords
Related Articles
- EP ID EP490530
- DOI 10.18231/2456-9267.2018.0002
- Views 135
- Downloads 0
Cytomorphology of breast lesions with historadiological correlation in a tertiary care centre of Puducherry
Introduction Breast cancer is the leading cause of morbidity amp mortality worldwide Breast being a surface organ is easily palpable for aspiration Diagnosis is often done by correlating fineneedle aspiration cytology FN...
Prominant squamous metaplasia with extensive myxoid degeneration and associated ischaemic infarction in fibroadenoma of breast: A diagnostic dilemma
Fibroadenoma is the most commonly diagnosed benign tumour in adolescents and young women Squamous metaplasia and prominent myxoid degeneation with associated ischaemia infarction is not a common finding without history o...
Micronucleus and its significance in spectrum of cervical lesions
Introduction: Cervical cancer remains second most common cancer among the women worldwide despite effective screening methods. Micronuclei (MN) test on exfoliated cells have been one among tests used in cancer screening....
Prospective study of Meningioma & diagnostic validity of MIB-1 index in grading of meningioma
Background: Meningioma is one of indolent neoplasm. Meningiomas may make their appearance in childhood or adolescence, but most are encountered in middle or later adult life. Females are affected more commonly than males...
A study of papanicolaou stain and cervical acid phosphatase papanicolaou stain in the detection of cervical intra epithelial neoplasm a comparative study
Introduction In order to increase the sensitivity of the routine PAP test a new test was introduced called the CAPPAP test In this test lysosomal enzyme and cervical acid phosphatase CAP enzyme are labeled with conventio...