Endometrial estrogen and progesterone receptors in infertility and abnormal uterine bleeding
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2018, Vol 3, Issue 1
Abstract
Introduction Evaluation of endometrial histology can be made more meaningful with the study of Estrogen and Progesterone receptor ER and PR status Present study aimed at studying ER and PR status of normal endometrium and endometrium in infertility and abnormal uterine bleeding and elucidating its relevance and utilityMaterials and Methods This case control study was carried out on prospectively registered patients It included 12 cases of infertility 24 cases of abnormal uterine bleeding 14 cases of uterine leiomyoma and 22 cases of age matched controls undergoing endometrial sampling for causes other than above mentioned conditions The cases were subjected to thorough clinical evaluation The study of endometrium was done with routine histology Endometrial ER and PR expression was studied immunohistochemically The data collected was analyzed to find out the variability of expression of endometrial ER and PR in normal and abnormal endometrium with studentrsquos ttest and correlation ttest SPSS software version 11Results The ER and PR expression in normal endometrium showed cyclical variation It was highest in the proliferative phase followed by the periovulatory phase followed by a significant decline in the late secretory phase In cases of infertility and abnormal uterine bleeding with endometrial dysfunction late secretory endometrium showed increased ER expression as compared to controlsConclusion Variations noted in endometrial ER and PR expression in infertility and abnormal uterine bleeding provided insight in its pathogenesis and helped in contemplating treatment optionsKeywords ER PR Endometrium Infertility Abnormal uterine bleeding Uterine leiomyoma
Authors and Affiliations
Vinanti Ajit Golwilkar, Meenal Vitthal Jadhav, Nalini Vinayak Kadgi
Keywords
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- EP ID EP490530
- DOI 10.18231/2456-9267.2018.0002
- Views 134
- Downloads 0
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