Endometriosis and Epigenetics: What do we Know?
Journal Title: Women's Health – Open Journal - Year 2018, Vol 4, Issue 1
Abstract
Objective Endometriosis is a common gynecological condition with a pathogenesis that is multifactorial and not well understood. The aim of this review was to explore the multiplicity of epigenetic changes in the field of this disease. Main Findings Epigenetic alterations in endometriosis may be classified into four main categories, with cross-reactions between these changes as well as genetic, environmental, hormonal factors, etc. Deoxyribonucleic acid (DNA) hypomethylation and hypermethylation control the transcription of several genes leading to the progression of this condition. Micro RNAs (miRNA) dysregulation controls ribonucleic acid (RNA) translation, degradation, and splicing. Immunologic changes involved downregulate the ability of immune cells to target shed cells. Furthermore, histone hypoacetylation and hyperacetylation affect the metabolism of steroids. Conclusion Endometriosis pathogenesis is a very wide and complex subject, associating several hypotheses. The epigenetic pathways discussed in this review may be the target of new more effective treatments in this field.
Authors and Affiliations
Georges Rameh
Keywords
Related Articles
- EP ID EP554976
- DOI 10.17140/WHOJ-4-125
- Views 137
- Downloads 0
Vitamin D Revisited: Impact on Osteoporosis
With the now widespread recognition that the prevention and treatment of osteoporosis has a major impact on healthcare, the various components and contributing factors to this condition is the subject of many recent and...
Perception of Fatigue in Female Nurses Employed in Hospitals
Background: Fatigue is the inability to maintain the required stamina in work capacity with consequences affecting occupational performance, health, and safety. Women are often more exposed to the risk of fatigue because...
Breast Cancer Screening and the AsianAmerican and Pacific Islander Communities
Years before the new breast cancer screening was established, whenever you hear about breast cancer, the buzz words was “early detection saves lives.” Translating this hype is easy: when breast cancer was found in its ea...
Chronic Diseases during Pregnancy and Birth Outcome: A Study Based on Tertiary Hospital of Mumbai
Background/Objective: Chronic disease has emerged as one of the most serious public health problems while disease prevalence during pregnancy had a greater risk of premature death and long-term illness. However, it is an...
Pregnant Women Never Drink Alone(Part 1)
Over the course of the next few months, the readers will be provided with a highly topical three part series of articles on the adverse impacts of alcohol on the human foetus, and thus on the offspring who suffer the con...