ENDOPHYTES FROM VIOLET PLANTS GROWING IN UZBEKISTAN AS A SOURCE OF PANCREATIC LIPASE INHIBITING COMPOUNDS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 9
Abstract
Obesity is one of the globally widespread diseases, accompanied by hypertension, hyperlipidemia, atherosclerosis, and type II diabetes. The most effective therapeutic approach for treating obesity is the inhibition of pancreatic lipase (PL). Eight isolates of endophytic fungi were obtained from Viola odorata growing in the park areas of Tashkent, Uzbekistan. Screening of PL inhibiting activity of secondary metabolites produced by isolates in vitro showed that the isolates expose inhibitory activity varying from 28.8 to 91,5 %. The extract of VО1R isolates from the root of V.odorata and identified as Aspergillus fisheri revealed the highest inhibition (91.5%), and a low IC50 value of 20 µg/ml is comparable with Xenical as standard. Phytochemical analysis showed that the VO1R extract contains alkaloids, terpenoids, tannins, and flavonoids.
Authors and Affiliations
Maftuna Yoldosheva, Tashkhan Gulyamova, Dilaram Ruziyeva, Kseniya Kondrasheva, Gulchekhra Rasulova
Keywords
Related Articles
- EP ID EP721763
- DOI 10.5281/zenodo.8397071
- Views 33
- Downloads 0
A METHODOLOGICAL MODEL OF DEVELOPING CREATIVE COMPETENCE OF STUDENTS IN ART POTTERY COURSES
The article is aimed at the formation of students' creative competence necessary to create an image in pottery, i.e. imaginative thinking, creative imagination, artistic observation, visual memory, emotional attitude to...
INFLUENCE OF ELECTRONIC DOCUMENT MANAGEMENT ON ORGANIZATION MANAGEMENT
This article examines the impact of electronic document management systems on the management of an organization using the example of a university. Automation of document flow can help improve the quality control of educa...
SOME CONSIDERATIONS ON SOCIAL INTELLIGENCE
In this article, some comments on the role and importance of social intelligence in personality development are made. It includes the functions of social intelligence, its importance in personal activity, and recommendat...
THE SET OF ABILITIES THAT CHARACTERIZE THE “PEDAGOGICAL SKILL” OF A TEACHER
The article focuses on the character of a teacher from pedagogical skill. The paper analyses pedagogy and set of abilities that can contain a range of characteristics
CANCER GENESIS: POSSIBLE MECHANISMS OF ITS DEVELOPMENT AND INHIBITION
In this article the changes that may occur during transformation of malignant are analyzed and developed its further theories and novelties around the discussed topic