Endosulphan Concentration alters biomarkers in albino rat
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
Effect of 11.01ppm of endosulfan dose on the enzyme Acid phosphatase and Alkaline phosphatase in liver and kidney of 5 week of swiss albino rat was studied for different period of exposure. The enzyme activity increased due to congestion, biliary hindrance and hyperplasia swelling of renal tubules and vacuolization. Phosphatase testing is used to assess enzymatic damage caused by kidney disease, liver disease, or a heart attack. Primary site of organochlorine storage in the body is adipose tissue. It is metabolized in the liver as a lipophilic xenobiotic to hepatotoxic intermediates by mono-oxygenase systems which cause oxidative stress. Increase in acid phosphatase and alkaline phosphatase activity is due to leakage of lysosomal enzymes into the cytoplasm and renal necrosis and pyknotic nuclei. Endosulphan effects the biomarker of albino rat.
Authors and Affiliations
Sabiha Khan| Department of Zoology, Govt. College, Ajmer, Rajasthan, India
Keywords
Related Articles
- EP ID EP14136
- DOI -
- Views 356
- Downloads 21
A comparative study on different market samples and standard samples of Shalaparni through physicochemical methods and near infrared spectroscopy
Dashmoolais one of the most important groups explained in Mishrakagana. One of which, Shalaparni is a potent drug used single as well as in various formulations mentioned in classics. Adulteration in Dashmoolaplants is...
Study of lipid profile in hypertensive subjects
Aim : The present study was designed to investigate lipid profile in hypertensive subjects. Material and Method : The present study was carried out on 25 healthy controls and 25 hypertensive subjects of either sex and...
UV Spectrophotometric Method development for Capecitabine in Eudragit and Chitosan based Microspheres and its Validation
A simple, rapid, accurate, precise, and economic Spectrophotometric method for Capecitabine in bulk and formulated microspheres dosage form has been developed. Capecitabine shows absorbance maximum at different waveleng...
Biological Properties and Uses of Honey: A Concise Scientific review
The global prevalence of chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer and Alzheimer's disease is on the rise. These diseases constitute the major causes of death globally. Honey is a...
Investigation of antiparkinsonian effect of Aloe vera on haloperidol induced experimental animal model
Background: Aloe vera (Family: Liliaceae) has been used for the treatment of diabetes, skin disorders and as an anti-inflammatory agent. There is increased concern about the side effects of conventional medicine in the...