Endothelial dysfunction and the role of hypertension in Nepalese subjects with major coronary risk factors
Journal Title: Nepalese Heart Journal - Year 2016, Vol 13, Issue 1
Abstract
Background and Aims: Hypertension is one of the major coronary heart disease risk factors. Endothelial dysfunction is thought to be the preclinical vascular changes in the pathogenesis of atherosclerosis and it its major manifestation; coronary heart disease. This study was designed to assess the endothelial function in subjects with major coronary risk factors including hypertension. Methods: The study was conducted in a tertiary referral centre in Central Nepal. A cross-sectional study was conducted on the cohort of 100 subjects with at least one out of six major coronary heart disease risk factors. JNC 7 criteria were used to defne hypertension. Brachial artery flow-mediated dilation was measured using high-resolution ultrasound. Endothelial dysfunction was defned as flow-mediated dilation value <9.99%. The association between endothelial dysfunction and hypertension was assessed by univariate and multivariate analysis. Results: Out of 100 subjects with coronary risk factors (mean age 46.75±9.95 years, mean number of risk factors 2.81±1.17), 65% subjects were hypertensive and 35% were non-hypertensive. Hypertension as a risk factor was evident in 80.39% and 48.98% subjects with abnormal and normal endothelial response respectively (p = 0.001). In addition, 63.08% and 28.57% subjects with and without hypertension had endothelial dysfunction respectively (p = 0.01). Hypertension was the only coronary risk factor associated with endothelial dysfunction in a multivariate model (p = 0.04). Conclusion: Hypertension was strongly associated with endothelial dysfunction and it could be the best predictor of endothelial dysfunction and subsequent coronary heart disease in coronary heart diseases risk factor cohorts.
Authors and Affiliations
Mani Prasad Gautam| Bharatpur Hospital, Bharatpur, Nepal, Samir Gautam| Gautam Buddha Community Heart Hospital, Butwal, Nepal, Usha Ghimire| Communication and Management Institute Private Limited, Kathmandu, Nepal, Sogunuru Guruprasad| Department of Cardiology, College of Medical Sciences, Bharatpur, Nepal Corresponding Author: Mani Prasad Gautam, Bharatpur Hospital, Bharatpur, Nepal, Rabin Bhattacharya| Department of Cardiology, College of Medical Sciences, Bharatpur, Nepal Corresponding Author: Mani Prasad Gautam, Bharatpur Hospital, Bharatpur, Nepal, Gangapatnam Subramanyam| Department of Cardiology, College of Medical Sciences, Bharatpur, Nepal Corresponding Author: Mani Prasad Gautam, Bharatpur Hospital, Bharatpur, Nepal
Keywords
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- EP ID EP15769
- DOI http://dx.doi.org/10.3126/njh.v13i1.14539
- Views 336
- Downloads 18
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