Endothelial Dysfunction Markers as Predictive of Nephropathy in Pediatric Type 1 Diabetes
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 10
Abstract
Abstract: Recent studies found a correlation between endothelial dysfunction and the development of diabetic nephropathy. Soluble intracellular adhesion molecule-1(sICAM) and nitric oxide metabolites (NOx) are known markers for endothelial dysfunction. This study aims at validation of the correlation between sICAM and NOx levels with the degree of microalbuminuria in pediatric type-1 diabetic patients. Thirty children with Type 1 diabetes (T1D) were enrolled for the study and compared to thirty healthy age and gender matched non-diabetic controls. In both groups, the levels of sICAM1, HBA1cpercentage, nitric oxide metabolites, and spot collection of urinary albumin / mg creatinine were measured. The results revealed that children with T1D had significantly higher glycated hemoglobin (HbA1c %) values versus the control group (P<0.05). The mean serum sICAM-1 concentration was significantly higher in T1D children versus the control group (P<0.05). 0n the other hand, the mean serum nitric oxide metabolite (NOx) showed a significant reduction (P< 0.05) in the T1D. The mean urinary albumin / mg creatinine was significantly higher (P< 0.05) in diabetic children than in control group. Correlation analysis showed a significant (P< 0.05) positive correlation between the levels of sICAM-1 µalbuminuria and a negative correlation between microalbuminuria and NOx level. It could be concluded that sICAM1and NO may play important roles in the pathophysiology and progression of endothelial dysfunction and its related disorders as diabetic nephropathy in T1D which should be considered in the monitoring the disease as well as for developing effective preventive and therapeutic interventions to prevent or retard overt diabetic nephropathy. Keywords:T1D, sICAM1, NOx, endothelial dysfunction, nephropathy
Authors and Affiliations
Ali KhairrallahAlzahrani
Keywords
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