Endothelial markers in high altitude induced systemic hypertension (HASH) at moderate high altitude
Journal Title: Medical Journal Armed Forces - Year 2017, Vol 73, Issue 4
Abstract
Background: Chronic intermittent hypoxia is known to induce systemic arterial hyperten- sion whereas chronic hypoxia causes pulmonary arterial hypertension. High altitude (HA) induced systemic hypertension (HASH) in previously normotensive lowlanders following acclimatisation and prolonged stay at moderate HA is a commonly encountered medical problem. HASH has been attributed to increased sympathetic discharge. Endothelial dysfunction (ED) is implicated in hypertension in the plains hence this study was conducted in HA. This is relevant especially because of the established role of ED in the aetiopathogenesis of HA illnesses. Since hypoxia may induce ED, we aimed at studying the association of endothelial dysfunction with HASH in temporary residents at HA. Methods: In this case–control single-centre study, we evaluated ED, by measuring endothelial molecular markers, soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor (VEGF) and endothelial selectin (E-Selectin) in 24 cases with HASH and 25 age, sex matched normotensive controls at moderate high altitude (11,500 ft).
Authors and Affiliations
Velu Nair
Keywords
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- EP ID EP615108
- DOI 10.1016/j.mjafi.2017.09.010
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