ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE T-786C POLYMORPHISM AMONG PREGNANT SUDANESE WOMAN IN KHARTOUM 2017
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 1
Abstract
A single nucleotide polymorphism (T > C) rs2070744 due to transition of a thymine to a cytosine at T-786C in the promoter region of eNOS was found to reduce the rate of mRNA transcription by 50%, resulting in decreased serum NO levels which can inhibit apoptosis or stimulate tumor proliferation, angiogenesis and metastasis. To evaluate the association between Nitric Oxide Synthase Gene T-786C polymorphism and pregnant woman in Sudan. A total of 40 patients pregnant woman and 50 control subjects were enrolled this study. DAN extrication samples were extracted from EDTA Blood using guanidine chloride method. Analysis of the eNOS786T > C promoter polymorphism were carried out by allele specific polymerase chain reaction method (PCR). The present study reported that, molecular analysis showed that, the most frequent genotype in patients was TT 95% (38) followed by TC genotype 5% (2). While in the control group there was 100% TT genotype. The present study indicates the lack of association between eNOS and pregnant woman which needs to be investigated in a study with larger samples.
Authors and Affiliations
Ebtihal Ahmed Mohammed
Keywords
Related Articles
- EP ID EP634900
- DOI -
- Views 143
- Downloads 0
ANTIMICROBIAL RESISTANCE OF BACTERIAL AGENTS OF THE UPPER RESPIRATORY TRACT AMONG HOSPITAL PATIENTS IN ASEER REGION, SAUDI ARABIA
Introduction: Antimicrobial resistance (AMR) is an internationally recognized threat to health. Microbial resistance to antibiotics has increased alarmingly over recent decades prompting the world health organization to...
SAFETY AND EFFICACY OF COMBINATION OF MONTELUKAST AND LEVOCETRIZINE IN THE SYMPTOMATIC TREATMENT OF ALLERGIC RHINITIS AND ASTHMA: PHASE IV CLINICAL STUDY
Introduction- Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction and treatment of AR symptoms requires a stepwise approach depending on the severity and duration of symptoms. A...
INVENTORY OF NECROPHAGOUS INSECTS INVOLVED IN THE DECOMPOSITION PROCESS OF A PIG CORPSE (SUS SCROFA DOMESTICUS L.) EXPOSED TO THE OPEN AIR IN THE SOUTHERN FOREST ZONE OF CÔTE D'IVOIRE
In Côte d'Ivoire, necrophagous insects have since 2008, begun to arouse a keen interest among researchers. After the first works by Adou (2014), on the anthropological aspects, of the colonization of a monkey corpse by i...
PALATAL RUGOSCOPIC ESTIMATION OF SEX AMONG IGBO STUDENTS IN THE UNIVERSITY OF PORT HARCOURT
Background: Estimating the sex and identity of an individual in post-mortem circumstances can be a very difficult process. However, due to the stability of palatal rugae under extreme conditions, its configuration can pr...
ANTIMICROBIAL ACTIVITY SCREENING OF ALLIUM TUNCELIANUM
Allium tuncelianum is locally cultivated in Tunceli, Turkey and it is an endemic garlic species. Antimicrobial activity of A. tuncelianum was tested against nine gram negative and eight gram positive bacteria (17 bacteri...