Endothelins and carcinogenesis
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Endothelins are a family of four endogenous peptides (ET-1, ET-2, ET-3, ET-4) secreted primarily in an inactive form by the endothelium. They are activated with the participation of converting enzyme. Numerous studies have described their pleiotropic biological activity. These peptides are involved, inter alia, in the regulation of processes such as cell proliferation, migration, angiogenesis and apoptosis. Their important role in the regulation of blood pressure, tissue perfusion (especially in the central nervous system), and myocardial systolic function is also known. Moreover, changes in transcriptional activity of endothelin and its receptors may be involved, with the participation of a number of signaling pathways, in carcinogenesis, and the pathogenesis of numerous diseases (heart, kidney, lung and skin disorders, especially with the component of fibrosis). Their role has been documented in the development of breast, prostatic, colorectal, ovarian, lung, kidney, and endometrial cancer, and in melanoma. In this article we present a brief description of the endothelin group and the participation of them and their receptors in carcinogenesis. We also try to show their role as prognostic and predictive factors in human malignant tumors. The article also refers to clinical trials on the use of preparations of endothelin receptor antagonists in the design of molecular therapeutic strategies in human malignancies.
Authors and Affiliations
Jacek Olender, Ewa Nowakowska-Zajdel, Katarzyna Walkiewicz, Małgorzata Muc-Wierzgoń
Keywords
Related Articles
- EP ID EP220842
- DOI -
- Views 131
- Downloads 0
Stygmatyzacja w dermatologii ze szczególnym uwzględnieniem chorych na łuszczycę
A stigma is currently defined as a discrediting mark, biological or social, that sets a person off from others and disrupts interactions with them. People who differ from social norms in some respect are often negatively...
Current views on etiopathogenesis of systemic lupus erythematosus
The article is a review of information concerning etiopathogenesis of systemic lupus erythematosus (SLE). Due to the risk of serious complications, including death, the clarification of etiology could result in substanti...
Influenza surveillance
Influenza surveillance was established in 1947. From this moment WHO (World Health Organization) has been coordinating international cooperation, with a goal of monitoring influenza virus activity, effective diagnostic o...
Czynniki genetyczne związane z podatnością na zakażenie HIV oraz z progresją zakażenia
Zakażenie HIV prowadzi do stopniowego upośledzenia układu odpornościowego człowieka, rozwoju AIDS i śmierci. Istotny wpływ na podatność i przebieg zakażenia mają czynniki genetyczne gospodarza. Ich działanie ocenia się,...
Mechanizmy angiogenezy nowotworowej
W początkowej fazie rozwoju guz nowotworowy nie wymaga obecności naczyń krwionośnych. Gdy jednak osiągnie wielkość około 2 mm3, tak jak inne tkanki, wymaga dostarczania tlenu i substancji odżywczych. Odbywa się to w wyni...