Endothelium depen dent factors of vasoconstriction (thromboxane B2) and vasodilation (6-prostaglandin F1α) in children with primary arterial hype rten sion
Journal Title: Medical Science Pulse - Year 2015, Vol 9, Issue 3
Abstract
Background: Vasoconstrictor and vasodilator substances imbalance play a major role in the formation of arterial hypertension. But the ratio between thromboxane B2 and 6-prostaglandin F1α in children with various forms of primary arterial hypertension (PAH) are insufficiently studied.Aim of the study: to explore the features of the content of thromboxane B2, 6-keto-PGF-1alfa and their correlation in children with different clinical and pathogenetic forms of PAH.Material and methods: The study involved 83 children aged 9 to 17 years. The first group included 32 children with stable PAH, the second – 32 children with labile PAH, the third (control group) – 21 children with normal blood pressure. TXB2 and 6-PGF1α serum levels were investigated by ELISA. All children were held ambulatory blood pressure monitoring (ABPM).Results: Average TXB2 levels in boys were 25,05 ±6,43 ng/ml at stable PAH and 27,26 ±11,26 ng/ml at labile PAH, which exceeded their levels in the control group (p < 0,05). Girls’ TXB2 level was elevated at labile PAH (to 11,06 ±1,79 ng/ml, p < 0,05) and did not differ from the control group at stablePAH. Girls’ 6-PGF1α level was up to 3,41 ±0,52 ng/ml at stable PAH and up to 2,63 ±0,25 ng/ml at labile PAH.Conclusions: Violation of the ratio between endothelial vasoconstriction (thromboxane) and vasodilatation (prostacyclin) factors in boys with PAH is due to increased TXB2 levels comparedwith children with normal blood pressure (p < 0,05). Girls with PAH have better compensatory vasodilation opportunities compared with boys according to increased prostacyclin production. That prevents the progression of endothelial dysfunction and PAH stabilization in girls.
Authors and Affiliations
Yu riy Marushko, Tatiana Hyschak
Keywords
Related Articles
- EP ID EP76783
- DOI 10.5604/2081-2021.1170707
- Views 164
- Downloads 0
Różnorodność rytmu serca jako wskaźnik rezerwy adaptacyjnej układu sercowo-naczyniowego
Wstęp: Skuteczność działania wegetatywnej regulacji może być kontrolowana przy pomocy oceny zmienności rytmu serca (HRV). Metoda ta przez ostatnie 10 lat zyskała popularność na całym świecie. Analiza licznych obserwacji...
Causes and efects of cave accidents in the area of Kraków-Częstochowa upland
Background: Mountain’s caves should be characterized by a set of unique rules and those who comply with them may be rewarded with the opportunity to experience memorable, worth cherishing moments. There are plenty of thr...
Występujące objawy i rola opieki pielęgniarskiej nad dzieckiem z biegunką o etiologii rotawirusowej
Wstęp: Rotawirus jest przenoszony drogą fekalno-oralną oraz kropelkową podczas bliskiego kontaktu z osobą zakażoną. Wirusem najczęściej zostają zakażone dzieci do 5. roku życia. Do działań profilaktycznych należą przestr...
Soccer players' injuries at different levels of the sport/ Kontuzje piłkarzy nożnych o różnym poziomie zaawansowania sportowego
Introduction: Soccer players are injury prone, and increasing competition - especially at the highest level - leads to increasing training loads, and these may contribute to more injuries to players. Hence, the aim is to...
Measurement and analysis of the gentle touch sensation in healthy people according to the author's test algorithm
Introduction: There are five basic types of sensation: vibration, poses, gentle touch, pain and temperature. The literature says that to study gentle sensation can be used cotton ball or finger. It is important that the...