Endothelium-dependent and independent effect of Guibourtia tessmannii (Caesalpiniaceae) on vascular contractility of rat
Journal Title: UNKNOWN - Year 2019, Vol 8, Issue 3
Abstract
The stem barks of Guibourtia tessmannii (Caesalpiniaceae) are used in traditional Gabonese medicine as antihypertensive remedies. In the present study, we investigated vasorelaxant properties effect of aqueous extract from G. tessmannii and fuller understanding these mechanisms of action in vitro. The activity of Guibourtia tessmannii was evaluated on isolated aorta rings of rat constricted with KCl (80 mM) and norepinephrine (10-4 M). Cumulative concentrations (1 mg/mL - 100 mg/ml) of G. tessmannii provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl (95.69 ± 0.6% and 91.34 ± 4.90%, respectively). The vasorelaxant effect induced by G. tessmannii on the aorta precontracted by KCl was significant decreased in presence of Nω-nitro-L-arginine methyl ester (11.30 ± 4.3 %, p<0.05), tétraéthylammonium (52.2 ± 9.20 %, p<0.01). Indomethacin and atropine modify the vasorelaxant effect of plant extract (57.13± 6.9 %, p<0.01 and 58.83± 5.9 %, p<0.01, respectively. These results suggest that the vasorelaxant action of G.tessmannii was mediated via the muscarinic receptors. The direct effect of G.tessmannii to be mediated by alpha-adrenergic receptors and potassium channels.
Authors and Affiliations
Koumba Madingou Noreen Orianna, Aworet Samseny Reine Raissa, Souza Alain, Saba-benedyo Traore Alfred
Keywords
Related Articles
- EP ID EP609295
- DOI -
- Views 90
- Downloads 0
Role of phytotherapy in diabetic neuropathy and neurodegeneration: from pathogenesis to treatment
Diabetes mellitus is a metabolic disorder associated with structural and functional alterations of various organ systems. Tissue injury is attributed primarily to chronic hyperglycemia. Diabetic complications are associa...
Biological activities of Chromolena odorata (L.) King and Robinson (Asteraceae) collected from Sabah, Malaysia as protein phosphatase type-1 inhibitor
Chromolena Odorata has been traditionally used as wound healer in local community. The present study investigated the anti-kinase and anti-phosphatases activities on methanolic C. odorata extract. Mutant yeast strains us...
Phytochemistry and proximate composition of root, stem bark, leaf and fruit of desert date, Balanites aegyptiaca
Balanites aegyptiaca or Desert date is a common plant in all dry lands of Africa and South Asia. Some parts of the plant are used as fish poisons but not poisonous to man. It is also used as medicine or food in humans as...
Phytochemical analysis of Leucaena leucocephala on various extracts
The plants play a vital role in human life. Every plant has some disease curative properties in it. Even the fodder plants have medicinal properties. In the similar way the present research was carried out to study phyto...
Evaluation of phytochemical, antioxidant and cytotoxic potential of Sesbania grandiflora Linn
Sesbania grandiflora Linn. is perennial branching, small erect quick-growing short-lived soft-wooded tree, mostly cultivated in southeast Asian countries including India and grows primarily in hot, humid environments. Th...