Endurance training increases exercise-induced prostacyclin release in young, healthy men - relationship with VO(2max).
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 3
Abstract
In the present study, we evaluated the effect of 5 weeks of moderate-intensity endurance training on the basal and exercise-induced systemic release of prostacyclin (PGI(2)), as assessed by plasma 6-keto-PGF(1alpha) concentration. Twelve physically active young men with the following characteristics participated in this study (the mean +/- SD): age, 22.7 +/- 2.0 years; body mass, 76.8 +/- 8.9 kg; BMI, 23.48 +/- 2.17 kg x m(-2); and maximal oxygen uptake (VO(2max)), 46.1 +/- 4.0 ml x kg(-1) x min(-1). Plasma 6-keto-PGF(1alpha) concentrations were measured in venous blood samples taken prior to the exercise and at exhaustion (at VO(2max)) before and after completing the training protocol. On average, the training resulted in a significant increase in VO(2max) (p = 0.03), power output at VO(2max) (p = 0.001) and a significant increase (p = 0.05) in the net-exercise-induced increase in plasma 6-keto-PGF(1alpha) concentration (Delta6-keto-PGF(1alpha) i.e., the difference between the end-exercise and pre-exercise 6-keto-PGF(1alpha) concentrations). No effect of training on the basal PGI(2) concentration was found. Interestingly, within the study sample (n = 12), two subgroups could be defined with a differential pattern of response with respect to Delta6-keto-PGF(1alpha) concentrations. In one subgroup (n = 7), a significant increase in Delta6-keto-PGF(1alpha) concentration after training was found (p < 0.02) (responders). This enhancement in the exercise-induced PGI(2) release was accompanied by a significant (p < 0.05) increase in VO(2max) after training. In contrast, in another subgroup (n = 5), there was no observed effect of training on the Delta6-keto-PGF(1alpha) concentration and the VO(2max) after training (non-responders). In both of these subgroups, training did not influence the basal PGI(2) concentration. In conclusion, the endurance training resulted in the adaptive augmentation of the systemic release of PGI(2) in response to exercise, which plays a role in the training-induced increase in VO(2max) in young, healthy men. The impairment of the training-induced augmentation of PGI(2) release in response to exercise demonstrated in the non-responders subgroup may predispose them to increased cardiovascular risk during vigorous exercise.
Authors and Affiliations
Jerzy Żołądź, Joanna Majerczak, Krzysztof Duda, Stefan Chłopicki
Keywords
Related Articles
- EP ID EP160278
- DOI -
- Views 105
- Downloads 0
Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats.
It has been recognized that the stress-related peptides are involved in anxiety states. Angiotensin II receptor blockade by systemic administration of the AT(1) receptor antagonists has been proposed as a new treatment p...
Red blood cells (RBCs), epoxyeicosatrienoic acids (EETs) and adenosine triphosphate (ATP).
In addition to serving as carriers of O(2), red blood cells (RBCs) regulate vascular resistance and the distribution of microvascular perfusion by liberating adenosine triphosphate (ATP) and epoxyeicosatrienoic acids (EE...
Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.
In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The large MI was produ...
Effect of combined treatment with mirtazapine and risperidone on the MK-801-induced changes in the object recognition test in mice.
Background: Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve treatment of the negative and certain cognitive symptoms of schizophrenia. Met...
C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers.
The functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the ABCB1 gene encoding the xenobiotic transporter P-glycoprotein (P-gp) may influence susceptibility to several diseases, as well as the clinical...