ENHANCEMENT OF BIOAVAILABILITY THROUGH INCREASE IN DRUG PERMEATION, STABILITY AND RETENTION TIME
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
The rate and extent to which an unchanged drug reaches the systemic circulation is called as bioavailability (BA). Bioavailability, a subcategory of absorption is one of the principal pharmacokinetic parameter determined for an active substance form a pharmaceutical product. It also indicates the fractional extent to which a dose of drug reaches its site of action or biological fluid from which the drug has access to its site of action. Physical properties of drug, drug formulation, route of administration, gastric emptying rate etc. are several factors affect the bioavailability of drug from its drug product. Poor solubility, enzymatic and transporters barrier, drug stability and short retention of the drug in stomach due to peristaltic movement are several factors decrease the bioavailability of the drug. This review deals with the bioavailability improvements techniques from poor permeation, lesser stability and short retention of the drug in stomach. Lipid based formulations; ion pairing and use of permeation enhancer are different methods to enhance the bioavailability through increase in permeation. Enteric coating, complexation and metabolism inhibitors lead to increase in drug stability. Bioadhesive polymers in formulation improve the gastro retention time serve as improved bioavailable product.
Authors and Affiliations
Vishal Sachdeva, Mahesh Kataria
Keywords
Related Articles
- EP ID EP141060
- DOI 10.7897/2230-8407.04513
- Views 88
- Downloads 0
A COMPARATIVE STUDY OF ANTI OXIDANT PROPERTIES IN COMMON INDIAN SPICES
The present study reports the anti-oxidant potential of the methanolic extract of three spices Syzygium aromaticum, Elettaria cardamom, Piper nigrum. The total phenolic content was high 36.63 mg GAE/g in the Syzygium aro...
KANJI: AN AYURVEDIC FERMENTATIVE PREPARATION
Kanji – A unique Ayurvedic fermentative preparation was prepared as per the textual reference Rasayanasara which is mainly indicated for the Shodhana (purification) of Metals and also for various mercurial processing. Bu...
VALIDATED SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND FURAZOLIDONE IN PURE AND IN TABLET DOSAGE FORM
Two methods are developed for simultaneous estimation of metronidazole and furazolidone in pure and in tablet dosage form by using distilled water as a solvent. Quantitation was carried out by the proposed methods namely...
PEG - MEDICATED CATALYST: FREE SYNTHESIS OF HANTZSCH 1, 4 – DIHYDROPYRIDINES OF AZELNIDIPINE AND NIFEDIINE
Hantzsch 1, 4 – dihydropyridines derivative of Azelnidipine and Nifediine were synthesized in good yield by PEG- medicated, catalyst free synthesis under solvent – free conditions. The product was directly recrystallized...
A NEW OXOTIRUCALLOIC ACID FROM THE STEM BARK OF MANGIFERA INDICA VAR. “LANGRA”
Phytochemical investigation of the ethanolic extract of the stem bark of Mangifera indica variety “Langra” yielded three new phytoconstituents characterized as n-docosan-18′-one-22′-ol-1′-yl hexanoate, 20(R), 24(R)-3-oxo...