ENHANCEMENT OF DISSOLUTION PROPERTIES OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE USING SYLYSIA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The objective of present study was to enhance the dissolution rate of Carvedilol (CAR) by using Solid dispersion technique. Solid dispersions in water soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability of a range of hydrophobic drugs. The poor solubility of Carvedilol leads to poor dissolution and hence variation in bioavailability. Carvedilol (CAR) is a beta blocker drug. In the present investigation Solid dispersions (SD) were prepared by employing different grades of silica gel (Sylysia). They were prepared by Solvent evaporation and kneading methods in three different mass ratios 1:1, 1:2 and 1:3. Comparison of the methods was also investigated. Physicochemical characterisation of disperse systems was carried out using differential scanning calorimetry(DSC), fourier transform infrared spectroscopy(FTIR). Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release. The prepared Solid dispersions were also evaluated for precompression parameters like angle of repose, bulk & tapped density, drug content, Carr's index and Hausner's ratio. Improved dissolution was observed in 1:3 ratio disperse system of kneading method compared to solvent evaporation method. Physicochemical characterisation results suggested that CAR existed in amorphous form in all dispersion systems which show that dissolution can be enhanced.
Authors and Affiliations
A. Bharathi*, , M. CH. Phanindra , G. Priyanka , S. Roja
Keywords
Related Articles
- EP ID EP90294
- DOI -
- Views 228
- Downloads 0
NANOHYDROGEL DRUG DELIVERY: A REVIEW
ABSTRACT Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insolu...
FORMULATION AND EVALUATION OF NEVIRAPINE LOADED CHITOSAN AND EUDRAGIT NANOPARTICLES FOR ANTIRETROVIRAL THERAPY
The goal of the present investigation was to formulate and evaluate chitosan and Eudragit® nanoparticles of nevirapine for antiretroviral therapy. Nanoparticles of nevirapine were prepared using chitosan, Eudragit® S 100...
EVALUTION OF ANTIASTHMATIC ACTIVITY OF CALOTROPIS GIGANTEA ROOTS
The present study deals with the effect of ethanolic extract of roots Calotropis gigantea by using various in vivo and in vitro animal models. In vitro model like isolated guinea pig ileum preparation was studies to know...
A SILENT CRISIS: RECENT DRUG DISCOVERY IN CANCER RESEARCH
This article represents the recent drug discovery in cancer research. Cancer is a term which describes a group of perhaps 120 different diseases which share some broad similarities. The body is made up of hundreds of mil...
DRUG TARGETING: BASIC CONCEPTS AND NANOSYSTEMS IN DRUG TARGETING
At present about 95% of all new potential therapeutic have poor pharmacokinetic and pharmacodynamics property. Either they get destroyed before going to systemic circulation or they get poorly absorbed. Hence, there is n...