ENHANCEMENT OF DISSOLUTION PROPERTIES OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE USING SYLYSIA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The objective of present study was to enhance the dissolution rate of Carvedilol (CAR) by using Solid dispersion technique. Solid dispersions in water soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability of a range of hydrophobic drugs. The poor solubility of Carvedilol leads to poor dissolution and hence variation in bioavailability. Carvedilol (CAR) is a beta blocker drug. In the present investigation Solid dispersions (SD) were prepared by employing different grades of silica gel (Sylysia). They were prepared by Solvent evaporation and kneading methods in three different mass ratios 1:1, 1:2 and 1:3. Comparison of the methods was also investigated. Physicochemical characterisation of disperse systems was carried out using differential scanning calorimetry(DSC), fourier transform infrared spectroscopy(FTIR). Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release. The prepared Solid dispersions were also evaluated for precompression parameters like angle of repose, bulk & tapped density, drug content, Carr's index and Hausner's ratio. Improved dissolution was observed in 1:3 ratio disperse system of kneading method compared to solvent evaporation method. Physicochemical characterisation results suggested that CAR existed in amorphous form in all dispersion systems which show that dissolution can be enhanced.
Authors and Affiliations
A. Bharathi*, , M. CH. Phanindra , G. Priyanka , S. Roja
Keywords
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