Enhancement of Dissolution Rate of Gliclazide by Liquisolid Technique
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
The purpose of the present research was to investigate the in vitro dissolution properties of poorly water soluble gliclazide by utilizing liquisolid technique. Avicel PH 102 and Neusilin were employed as carrier material; Aerosil 200 as coating material and crosspovidone as disintegrant respectively for preparing liquisolid compacts. Liquisolid compacts were prepared and evaluated for their tabletting properties. The tabletting properties of the liquisolid compacts were within the acceptable limits and drug release rates of all prepared LS compacts were distinctly higher as compared to directly compressed tablets, and marketed tablets. The results showed that liquisolid compacts demonstrated significantly higher drug release rates than those of conventionally prepared directly compressible tablets. This was due to an increase in wetting properties and surface of drug available for dissolution. From this study it concludes that the LS technique is an effective approach to enhance the dissolution rate of gliclazide. Keywords: Liquisolid compacts (LS), Gliclazide, Dissolution rate, Liquid load factor.
Authors and Affiliations
Patel Dhara, Anmol Eldose, Upadhyay Umesh, Jain Hitesh
Keywords
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