Enhancement of Hepatoprotective Effect of Herbal Formulation (F1) on Carbon tetrachloride and Ethanol Induced Liver Toxicity in Albino Rats
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 7
Abstract
There are several plants and formulations which are recommended for the treatment of liver diseases. The formulation F1 was composed with Andrographis paniculata (Kalmegh), Boerhavia diffusa (Punarnava), Eclipta alba (Bhringraj) and Picrorhiza kurroa (Kutki). In present study, an Herbal formulation was evaluated for its hepatoprotective effects against carbon tetrachloride and alcohol induced hepatocellular injury in rats. Hepatotoxicity was induced in male Charles foster rats by administering CCl4 (1ml/kg, p.o., diluted in liquid paraffin) and ethanol (36.6%) 30 ml/kg/day p.o. Herbal formulation at the doses of 100, 200 and 400 mg/kg and silymarin as standard 50mg/kg were administered p.o. The hepatoprotective assessment was done by estimating biochemical parameters: alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, alkaline phosphatase, albumin, triglycerides, lipid peroxidation (TBARS) and glutathione. The histopathological studies were also done to estimate the extent of tissue injury. Herbal formulation markedly reversed the toxic effects caused by CCl4 and ethanol intoxication as evidenced with serum and tissue biochemical parameters; similar to silymarin. Herbal formulation has also restored the cellular integrity of liver architecture after CCl4 and ethanol exposure. The results of the study strongly indicate that the Herbal formulation has potential hepatoprotective action against CCl4 and ethanol induced hepatic damage in rats.
Authors and Affiliations
Munish Kumar*| Swami Devi Dyal Institute of Pharmacy, Barwala, Haryana, Panchkula, India, Hayat M. Mukhtar| Shaheed Bhagat Singh College of Pharmacy, Patti, Tarntarn, Amritsar, Punjab, India, Rohit Goyal| School of Pharmaceutical Sciences, Shoolini University, Solan, H.P, India, Renu Goyal| Indian Institute of Integrative Medicine, Department of Natural Product Chemistry, CSIR Lab, Jammu Tawi, J & K. India, Vijay Singh Nain| Swami Devi Dyal Institute of Pharmacy, Barwala, Haryana, Panchkula, India
Keywords
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