ENHANCING SOLUBILITY AND DISSOLUTION OF IBUPROFEN BY SPRAY DRYING USING PLURONIC F127
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
Ibuprofen, an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Ibuprofen by preparing microspheres by spray drying technique. Ibuprofen microspheres containing different ratio of F127 were produced by spray drying using dichloromethane as solvent to enhance solubility and dissolution rate. The prepared formulations containing different ratio of drug and polymer were evaluated for in vitro dissolution and solubility. The prepared formulations were characterized by scanning electron microscopy, differential scanning calorimeter, X-ray diffraction and Fourier transform infrared spectroscopy. Dissolution profile of the spray dried microspheres was compared with its physical mixture and pure sample. Spray dried microspheres exhibited decreased crystallinity and the solubility and dissolution of the microspheres containing different ratio of drug and pluronic F127 were significant improved compared with its physical mixture and pure sample of Ibuprofen. Dissolution of microspheres containing 1:3 w/w (SD 3) showed higher % release i.e. 94 % in 60 min compare to other formulation. Consequently, Hence, From the above result it can be conclude that spray dried microspheres of Ibuprofen is a useful technique to improve the solubility and dissolution of poorly water soluble drug like Ibuprofen.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Selvam Panner
Keywords
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