ENVIRONMENTAL RESPONSIVE HYDROGELS: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2012, Vol 2, Issue 1
Abstract
Hydrogels are three dimensional crosslinked hydrophilic polymeric networks which has the capability to imbibe water or biological fluids. Environmentally responsive hydrogels have the ability to respond to change in their external environment. They can exhibit dramatic changes in their swelling behaviour, network structure, permeability and mechanical strength in response to change in pH or ionic strength of the surrounding fluid or temperature. Other hydrogels have the ability to respond to applied electric or magnetic field or to change in concentration of glucose. Environmental responsive hydrogels for drug delivery application also requires biocompatibility. The chemical structure of the polymer may also affect the swelling ratio of hydrogels. Hydrogels containing hydrophilic groups swell to a higher degree compared to those containing hydrophobic groups. Swelling of environmentally responsive hydrogels can be affected by changes in the temperature of the swelling media, ionic strength and pH
Authors and Affiliations
Anish Gupta, Abdul Siddiqu
ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA)
The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry). Withania somnifera, commonly known as Ashwagan...
MEMORY ENHANCING ACTIVITY OF HYDROALCOHOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES
The present study was to evaluate the effect of Terminalia catappa on cognitive functions and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The extract of Terminalia catappa was administered orall...
EFFECT OF NITROGEN SOURCE FOR THE BIOSYNTHESIS OF XYLANASE FROM ASPERGILLUS TAMARII
The main aim of the study is to enhance the biosynthesis of xylanse by incorporating nitrogen sources (both organic and inorganic). Recently, xylanases have expanded their use in many processing industries, such as pulp...
COMPARATIVE EVALUATION OF AMISULPRIDE AND ESCITALOPRAM ON SHEEHAN’S DISABILITY SCALE AMONG DEPRESSION PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL IN NEPAL
Introduction and Aim: Depression is an important global public health problem due to its relatively high lifetime prevalence and significant disability caused by it. The present study was conducted to compare improvement...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF OLANZAPINE IN MARKETED FORMULATION
A simple, accurate, precise and rapid stability indicating RP-HPLC method was developed and validated for the analysis of Olanzapine in marketed formulation. Analysis was performed on a C-18 (250mm x 4.60mm, 5 µm) column...