ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 4
Abstract
Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.
Authors and Affiliations
Saruchi Sharma, VANEET KUMAR
Keywords
Related Articles
- EP ID EP565407
- DOI 10.22159/ijpps.2019v11i4.31043
- Views 73
- Downloads 0
Stability Indicating Spectrophotometric Methods Determination of Nicardipine in the Presence of its Alkaline Induced Degradation Products
Objective: Derivative, ratio spectra derivative and ratio difference spectrophotometric methods were developed and validated for simultaneous determination of Nicardipine (NIC) in the presence of its alkaline induced deg...
SOCIODEMOGRAPHIC PROFILE OF PATIENTS WITH ACUTE POISONING IN THE EMERGENCY WARDS OF A TERTIARY CARE HOSPITAL
Objective: To assess the socio-demographic profile and outcomes in the patients with poisoning admitted to the emergency wards of a tertiary care hospital.Methods: The prospective observational study was conducted for a...
ANTIBACTERIAL AND ANTICANCER ACTIVITIES OF MARINE BACTERIAL EXTRACTS AND DETECTION OF GENES FOR BIOACTIVE COMPOUNDS SYNTHESIS
Objective: This study was aimed to determine the antimicrobial, toxicity, and anticancer activities of ethyl acetate extracts from sponge-associated bacteria and to detect the presence of PKS and NRPS genes.Methods: Crud...
THE BLISS YOGA INCULCATES DURING THE DIFFERENT STAGES OF PREGNANCY
Yoga is the Sanskrit word for ‘union’, and through the practice of yoga the mind, body and breath are united. During pregnancy one lives and breathes with her baby and the baby becomes aware of her thoughts, movement...
SYNTHESIS AND MOLECULAR DOCKING STUDY OF 2-ARYL/HETEROARYL-6-CHLOROQUINOLINE-4-CARBOXYLIC ACIDS WITH PLASMODIUM LDH RECEPTOR PROTEIN
Objective: Synthesis and in silico molecular docking studies of 2-aryl/heteroaryl-quinoline-4-carboxylic acid derivatives (3a-j) with plasmodium LDH receptor protein.Methods: The 2-aryl/heteroaryl-quinoline-4-carboxylic...