Eosinophilic esophagitis—Where are we today?

Journal Title: Jornal de Pediatria - Year 2019, Vol 95, Issue 3

Abstract

Objective The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. Sources A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed. Summary of the findings The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients. Conclusions Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.

Authors and Affiliations

Cristina Ferreira

Keywords

Related Articles

Hospitalizations of children with sickle cell disease in the Brazilian Unified Health System in the state of Minas Gerais

Objective To identify and characterize hospital admissions and readmissions in the Brazilian Unified Public Health System (Sistema Único de Saúde [SUS]) in children with sickle cell disease diagnosed by the Minas Gerais...

Infection with multidrug-resistant gram-negative bacteria in a pediatric oncology intensive care unit: risk factors and outcomes

Objective This study aimed at evaluating the predictors and outcomes associated with multidrug-resistant gram-negative bacterial (MDR-GNB) infections in an oncology pediatric intensive care unit (PICU). Methods Data wer...

Asthma control in the quality of life levels of asthmatic patients’ caregivers: a systematic review with meta-analysis and meta-regression

Objective To perform a systematic review with meta-analysis and meta-regression to correlate the total scores of asthma control with the increase in the total scores of health-related quality of life levels of parents of...

High-frequency profile in adolescents and its relationship with the use of personal stereo devices

Objective To analyze and correlate the audiometric findings of high frequencies (9–16kHz) in adolescents with their hearing habits and attitudes, in order to prevent noise-induced hearing loss. Method This was a descrip...

Pediatric decision limits for lipid parameters in the Brazilian population

Disorders of lipid and lipoprotein metabolism are commonly observed in obese and insulin resistant states, and are often referred to as diabetic dyslipidemia. Diabetic dyslipidemia is characterized by high plasma triglyc...

Download PDF file
  • EP ID EP575265
  • DOI 10.1016/j.jped.2018.06.012
  • Views 47
  • Downloads 0

How To Cite

Cristina Ferreira (2019). Eosinophilic esophagitis—Where are we today?. Jornal de Pediatria, 95(3), 275-281. https://europub.co.uk/articles/-A-575265