Ephedrine-caffeine mixture in wet-cold stress.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 3
Abstract
Our investigations were aimed at studying the possibility of enhancement of homeostatic processes protecting against excessive body cooling by using thermogenic drugs. We studied the influence of ephedrine (1 mg/kg) and caffeine (2.5 mg/kg) mixture in males immersed in cold water (12 degrees C) on core temperature and plasma catecholamines, cortisol, energy substrates and chosen cognitive functions in subjects without or after previous submission to short cold acclimation procedure by five repeated brief cold-water immersions. The tested drugs did not significantly influence core temperature during immersion both in acclimated and non-acclimated subjects, however, they enhanced metabolic response. There were observed faster mobilization and higher increase in energy substrates, more pronounced in acclimated subjects (free fatty acids, glucose). Tested drugs slightly improved some psychosomatic reactions. Although the results of our study suggest that a single application of ephedrine-caffeine mixture might probably support physiological mechanisms protecting against excessive body cooling when used in peoplein wet-cold conditions, further research is needed to confirm the clinical significance.
Authors and Affiliations
Marek Kowalczyk, Bożena Antkowiak, Oktawiusz Antkowiak, Robert Zdanowski, Anna Kłos
Keywords
Related Articles
- EP ID EP133888
- DOI -
- Views 104
- Downloads 0
Cost analysis of therapy for patients with multiple sclerosis (MS) in Poland.
Multiple sclerosis (MS) is a neurological disease of the central nervous system in which dissipated demyelination lesions develop. The currently available pharmacotherapy and rehabilitation for this disease aims to prese...
Effects of GABA(B) receptor ligands in rodent tests of anxiety-like behavior.
GABAergic hypothesis of anxiety was introduced many years ago, however, a limited number of supporting data were accumulated so far and the role of GABA(B) receptors in behavioral processes related to the anxiety disorde...
Role of polymorphonuclear leukocyte infiltration in the mechanism of anti-inflammatory effect of amiodarone.
In many physiological bodily functions, and in the pathogenesis of inflammation, ions are exchanged between intracellular and extracellular areas. Amiodarone is a multiple ion channel (Ca(++), Na(+), K(+)) blocking drug,...
MDR1 gene polymorphism in allogeenic kidney transplant patients with tremor.
P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene, which demonstrates functional polymorphism. It is present in endothelial cells of the blood-brain barrier. P-gp pays a role...
Mitochondrial biogenesis in cardiac pathophysiology.
Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the mai...