Epidemiological and Experimental Studies: The Role of Metformin on Colorectal Cancer
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2016, Vol 5, Issue 4
Abstract
GLOBOCAN data in 2012 showed colorectal cancer was the third leading cancer worldwide. In Indonesia, based on WHO data in 2014, colorectal cancer was the second common cancer ini men and third cancer in women. Epidemiological studies showed that diabetes mellitus have a correlation with the incidence of cancer and increase colorectal cancer risk by 30%. Some of epidemiological study showed that metformin therapy in diabetes patient reduce the risk of cancer incidence. It supported by experimental study which showed that metformin inhibit the growth and proliferation of cancer cells by influence the AMPK/mTOR pathway as a main role. The method was literature review based on publication at Pubmed, Scopus, and Google Scholar with keywords “metformin, colorectal cancer”, “metformin, colon cancer”, without index factor limitation in free journal and paid journal. The aim of this review is to give a new insight of metformin activity as anti-cancer and its potential for both preventif and adjuvant cancer therapy, especially for colorectal cancer.
Authors and Affiliations
Ratih D. Yudhani
Keywords
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- EP ID EP368880
- DOI 10.15416/ijcp.2016.5.4.258
- Views 81
- Downloads 0
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