Epidemiological Profile of Patients with Hemophilia at Tertiary Care Center of Western Uttar Pradesh
Journal Title: International Journal of Contemporary Medicine surgery and Radiology - Year 2018, Vol 3, Issue 4
Abstract
Introduction: Hemophilia is a rare, congenital, chronic and expensive to treat disorder. Hemophilia is not a disease of public health relevance in India because the focus of public health services in India is on the control of highly prevalent communicable diseases. In such circumstances the data collection related to hemophilia acquires very low priority. So this study was undertaken with objectives to describe the epidemiology of hemophilia patients at Government medical college in Western Uttar Pradesh and assess common complications and prevalence of hepatitis B, hepatitis C and HIV in relation to specific replacement therapy. Material and Methods: This is an observational cross sectional study which included 77 male subjects and are divided into 2 groups: group I (<18 years age) n=26 and group II (>18 years age) n=51. Patients with Hemophilia A and B who visited the hospital for treatment or factor replacement therapy were evaluated. The viral markers tested in these patients included Australia antigen (HBsAg), anti HCV antibody (anti-HCV-Ab), and antibodies against HIV (anti-HIV-Ab). Results: In our study the ratio of patients with hemophilia A to B in group I and group II was 7.6:1 and 7.5:1 respectively. Family history of hemophilia is present in 69.23% (group I) and in 49.02% (group II) patients. Significant association was found between family history and type of hemophilia in group I patients (P=0.005). A total of 77 male hemophiliacs with history of transfusion showed prevalence of 9.09% for Hepatitis-C, 7.35% for Hepatitis-B, and nil for HIV. Conclusion: Our study shows that hemophilia A is more common disorder than hemophilia B. Most common presenting symptom at the time of diagnosis was soft tissue bleeding and knee joint is the most commonly involved joint. Hepatitis C is the most frequently identified transfusion transmitted viral infection than Hepatitis B and HIV.
Authors and Affiliations
Yogita Singh, Devinder Kumar Vohra
Keywords
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- EP ID EP472506
- DOI 10.21276/ijcmsr.2018.3.4.23
- Views 89
- Downloads 0
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