Epidemiological study of endocrine disorders in patients with B-Thalassemia major in Kurdistan province in 2013

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Epidemiological study of endocrine disorders in patients with B-Thalassemia major in Kurdistan province in 2013

Journal Title: Khoon - Year 2018, Vol 15, Issue 2

Abstract

Epidemiological study of endocrine disorders in patients with B-Thalassemia major in Kurdistan province in 2013 Moradveisi V.1, Azizi S.2, Fathollahpour A.1, Khalafi B.2 1Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran 2Kurdistan University of Medical Sciences, Sanandaj, Iran Abstract Background and Objectives Major beta-thalassemia is a hereditary hemoglobinopaty that is characterized by a genetic deficiency in the synthesis hemoglobin polypeptide chain. The aim is to determine endocrine disorders such as diabetes, hypothyroid, hypo-parathyroid, low growth hormone, hypogonadism and deranged glucose tolerance test and their relation with sexuality, age, ferritin measure and Desferal beginning age in Kurdistan province in 2013. Materials and Methods In this descriptive study, all patients with major thalassemia over 3 year of age with treatment record in Sanandaj Besat Hospital were enrolled. For all patients, tests of GTT, LH, FSH, FSH.T3, T4, TSH, PTH, Ferritin were conducted. The demographic information together with the beginning age of Desferal use were added to the questionnaire. Data were then analyzed by T-test, Kscore, linear regression and logistic regression in STATA-11 software. Results Out of 43 patients, 20 had hypogonadism, 17 had low growth hormone, 2 diabetes, 4 hypoparathyroid, 3 hypothyroid, and 4 deranged glucose tolerance test result. We also found a significant corrrelation between hypogonadism with age, ferritin measure and the beginning age of the Desferal use. The correlation between deranged glucose tolerance test with ferritin measure was significant. There were no significant correlations between other variables. Conclusions This study showed that the prevalence rate of endocrine disorder in patients with thalassemia being more than healthy people. Therefore, all patients with major beta thalassemia over 15 years of age should undergo considerable clinical and laboratory evaluation for endocrine gland. Key words: Blood Transfusion , Endocrine Disease , beta-Thalassemia , Epidemiology Received: 18 Feb 2018 Accepted: 18 Apr 2018 Correspondence: Khalafi B., MD. Member of Student Research Committee of Faculty of Kurdistan University of Medical Sciences. P.O.Box: 66177-13446, Sanandaj, Iran. Tel: (+9887) 33664673; Fax: (+9887) 33664643 E-mail: khalafi.behzad70@gmail.com

Authors and Affiliations

V. Moradveisi, S. Azizi, A. Fathollahpour, B. Khalafi

Keywords

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EP ID EP322176
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