Epidemiology and clinical profiling of constipation predominant irritable bowel syndrome in India
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 8
Abstract
Irritable bowel syndrome (IBS) is regarded as disorder of brain gut axis, with altered central nervous system processing. Limited data is available regarding epidemiology and clinical profiling of constipation predominant IBS (IBS-C) in the general Indian constipated population. Hence the present study was conducted to evaluate the demographics, socio-economic and clinical characteristics in these patients. Patients (≥18 years) satisfying Rome-III criteria for IBS-C were enrolled in this prospective, multicentric, clinico-epidemiological study. Their demographics, socioeconomic status (Kuppuswamy scale), comorbid conditions, concomitant medications, severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (PAC-QoL) were assessed. Out of 925 patients of constipation, 226 (24.43 %) patients fulfilled the Rome-III criteria for IBS-C were enrolled; rest of 75.57 % patients had functional constipation. Mean age of study population was 43.8 ± 16.3 years (men: 65.5%; women: 34.5%); higher proportion of patients were from urban population compared to rural (62.0 % vs. 38.1 %). Patients had higher mean scores of education and occupation and belonged to upper socio-economic class. Patients had higher mean scores of PAC-SYM (30.1±4.9) and CSS (11.2±3), leading to poor quality of life (PAC-QoL: 42.2±13.6). Acid peptic disorders (APD; 21.7%) and hypertension (13.7%) were the most common comorbidities reported. Laxatives (50.9%), drugs for APD (40.7%), antihypertensive (14.2%) and antianxiety/antidepressants (12.8%) were the most commonly used concomitant medication. Higher educational/occupational scores point towards increased stress/anxiety, which could be attributed to dysfunctional brain-gut axis in IBS. Patients with IBS-C reported high frequency and severity of constipation-related symptoms, thereby leading to poor QoL. Moreover, these patients had higher prevalence of APDs, thus highlighting the need to identify the presence of upper gastrointestinal comorbidities in IBS patients. This study thus emphasizes the necessity for a multi-faceted approach for holistic management of IBS.
Authors and Affiliations
Ramesh Rooprai, Naresh Bhat, Rajesh Sainani, Rashmi Hegde
Keywords
Related Articles
- EP ID EP586586
- DOI -
- Views 175
- Downloads 0
Zirconia-Modern alloy/ceramic in Dentistry: A review
Zirconia (ZrO2) is a ceramic material with adequate mechanical properties for manufacturing of medical devices. Zirconia stabilized with Y2O3 has the best properties for these applications. When a stress occurs on a ZrO2...
Assessment of digital panoramic radiograph magnification on vertical measurement accuracy in posterior mandibular regions
Panoramic radiography is often the first choice method for the placement of implants because it provides information on the overall shape of the jaws, the position of the maxillary sinus floor and the nasal cavity floor,...
Recurrent hydatid cyst of the Pelvis: A rare case
Hydatic echinococcosis is preferentially localized to the liver. Primary bone localization is rare, characterized by high clinical latency, lack of radiological specificity and difficulties of its surgical treatment. We...
Analysis of the correlation of the air pollution indicator and metabolic syndrome in Pingtung area
Background: There are considerable evidences showing that air pollution in our environment is enough to damage health. The relation between air pollution and cardiovascular disease has been established by a large number...
Effectiveness of a pre-operative educational programme on pain and respiratory status of children undergoing elective abdominal surgery
Pain is inevitable when a child undergoes surgery. General anaesthesia and surgery directly affect the respiratory system. The present study is aimed to determine the effectiveness of a pre-operative educational programm...