Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

Journal Title: The AAPS Journal - Year 2013, Vol 15, Issue 3

Abstract

The online version of this article (doi:10.1208/s12248-013-9493-3) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Tien-Yuan Wu, Tin Oo Khor, Zheng-Yuan Su, Constance Lay-Lay Saw, Limin Shu, Ka-Lung Cheung, Ying Huang, Siwang Yu, Ah-Ng Tony Kong

Keywords

Related Articles

Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor

The knowledge of in vivo biotransformation (e.g., proteolysis) of protein therapeutic candidates reveals structural liabilities that impact stability. This information aids the development and confirmation of ligand-bind...

Pharmacodynamics-Mediated Drug Disposition (PDMDD) and Precursor Pool Lifespan Model for Single Dose of Romiplostim in Healthy Subjects

The objective of this study was to characterize the pharmacokinetics and pharmacodynamics (PK-PD) of romiplostim after single-dose administration in healthy subjects. The mean serum romiplostim concentrations (PK data) a...

AAPS/RAPS/CAPRA collaborative program: Exploring the challenges of drug regulation in a global environment: Clinical concerns

Globalization of the pharmaceutical industry has led to a need to harmonize the regulatory requirements governing the marketing of medicinal products. To minimize the barriers impeding global drug product registration, t...

Regulatory Perspectives on Strength-Dependent Dissolution Profiles and Biowaiver Approaches for Immediate Release (IR) Oral Tablets in New Drug Applications

Dissolution profile comparisons are used by the pharmaceutical industry to assess the similarity in the dissolution characteristics of two formulations to decide whether the implemented changes, usually minor/moderate in...

Microparticles for Inhalational Delivery of Antipseudomonal Antibiotics

Chronic pseudomonal bronchopulmonary infections in cystic fibrosis patients are frequently controlled with inhaled antibiotics. Dry-powder inhalable antibiotics are an attractive alternative to nebulized medications. We...

Download PDF file
  • EP ID EP681141
  • DOI  10.1208/s12248-013-9493-3
  • Views 75
  • Downloads 0

How To Cite

Tien-Yuan Wu, Tin Oo Khor, Zheng-Yuan Su, Constance Lay-Lay Saw, Limin Shu, Ka-Lung Cheung, Ying Huang, Siwang Yu, Ah-Ng Tony Kong (2013). Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors. The AAPS Journal, 15(3), -. https://europub.co.uk/articles/-A-681141