Epigenetic regulations of hematopoietic stem cells ageing and the regulation of traditional Chinese medicine
Journal Title: Traditional Medicine Research - Year 2016, Vol 1, Issue 2
Abstract
The current progress in the study of DNA methylation and histone modifications regulating HSCs ageing and the epigenetic role of TCM in the treatment of hematological malignancies were summarized. Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Given the essential role of a stem cell to self-renew, differentiate, and proliferate, it is no wonder that they are critically important to an organism during development and to tissue self-healing and regeneration. Hematopoietic stem cells (HSCs), as one of adult stem cells, have been well characterized recently. However, the regulation mechanism of HSCs ageing remains unclear. Epigenetic alterations are now recognized as a hallmark of mammalian ageing and involved in HSCs ageing. In addition, recent studies showed that HSCs ageing is related to hematological malignancies. Therefore, epigenetic modifiers maybe novel targets for hematological malignancies therapy. Traditional Chinese medicine (TCM) has been used to treat hematological malignancies for centuries. Here, we aim to review the current progress in the study of epigenetic changes regulating HSCs ageing, particularly focusing on the epigenome and its regulators in ageing HSCs. Furthermore, we will talk about the potential of TCM in treating hematological malignancies by regulating epigenetic changes.
Authors and Affiliations
Yang Dao-Zheng, Luan Xin-Yuan, Wang Shu-Bin
Keywords
Related Articles
- EP ID EP45295
- DOI 10.12032/TMR201602010
- Views 311
- Downloads 0
Effects of processing technology on essential oil and pharmacological action of frankincense
Background: According to the traditional Chinese medicine theory, the common processing methods for Ruxiang (frankincense) include stir-frying processing and vinegar processing. Methods: With network pharmacology and the...
Annual advances of Chinese minority traditional medicine in 2020
Chinese minority traditional medicine is a traditional medicine formed during the long-term medical practice of various ethnic groups and is the crystallization of the wisdom of the people in all ethnic groups in China....
Epigenetic regulations of hematopoietic stem cells ageing and the regulation of traditional Chinese medicine
The current progress in the study of DNA methylation and histone modifications regulating HSCs ageing and the epigenetic role of TCM in the treatment of hematological malignancies were summarized. Age-related defects...
Clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema
Objective: To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema. Methods: One hundred and twenty patients with chro...
Medicinal plant-based saponins targeting COVID-19 Mpro in silico
Background: Recently, the Chinese scientists Liu et al. demonstrated a crystallized form of severe acute respiratory syndrome coronavirus-2 main protease (Mpro), the best target of the drug, which was published in Nature...