ErbB Targeted Therapy in Endometrial Cancer
Journal Title: International Journal of Clinical Therapeutics and Diagnosis (IJCTD) - Year 2015, Vol 0, Issue 1
Abstract
The potential role of ErbB receptors (especially EGFR and ErbB-2) as targets for cancer therapy has been investigated for over 30 years. Anti-ErbB monoclonal antibodies (MoAbs) bind to the extracellular domain of EGFR or ErbB-2 and prevent ligand binding and receptor activation. They are an attractive and appropriate treatment option in patients with advanced, recurrent or metastatic endometrial cancer and with EGFR and ErbB-2 overexpression. ErbB-specific tyrosine kinase inhibitors (TKIs) block the binding of ATP to the intracellular domain of EGFR and/or ErbB-2 and prevent tyrosine kinase activity and subsequent intracellular signaling. They are another attractive and appropriate treatment option in patients with advanced, recurrent or metastatic endometrial cancer and with EGFR and ErbB-2 overexpression. The overall response rate to ErbB targeted therapies is modest, unless they are associated with chemotherapy or radiotherapy. Moreover, molecular targeted therapies have still shown modest effect in unselected endometrial cancer patients. Perhaps ErbB-targeted therapies may be used as adjuvant treatment in type II endometrial cancer patients with EGFR and ErbB-2 overexpression.
Authors and Affiliations
Georgios Androutsopoulos
Keywords
Related Articles
- EP ID EP202998
- DOI 10.19070/2332-2926-SI01002
- Views 127
- Downloads 0
Evaluation of Symptoms and Characteristic Features of Lead Poisoning and their Assistance in Clinical Decision Making
Aim of the present study is to evaluate the symptoms and characteristics features in lead based industrial workers and accessing their reliability in clinical decision making and diagnosing lead toxicity. Study involves...
Now Moments in Professional Care - The Importance of Positive Affect in Patient-Therapist Matching
Regarding clinical work, it is known that especially the positive affect shown to the patient and the continuous unwavering interest in the patient are the main criteria for a successful treatment and treatment planning....
Primary Adrenal Insufficiency (PAI): A Major Teaching Hospital Experience, Riyadh, Saudi Arabia
Background: Primary adrenal insufficiency (PAI) in children is an uncommon, but potentially fatal. The current symptoms include weakness, fatigue, anorexia, abdominal pain, weight loss, orthostatic hypotension, salt crav...
T-Helper Cell Cytokine Expression Profiling in Rheumatoid Arthritis Patients by Flow Cytometric Bead Array Analysis
Background: Rheumatoid arthritis (RA) is the most common chronic autoimmune disease affecting multiple joints. A chronic imbalance in cytokine production by T-helper (Th) cells is likely a key factor in RA development. O...
Picroside II Diminishes Oxidative Stress Induced By Cerebral Ischemic Injury In Rats
Objective: To optimize the therapeutic dose and time window of picrosede II in cerebral ischemic injury in rats by orthogonal test. Methods The forebrain ischemia model was established by a bilateral common carotid arter...