Erwin Chargaff (1905-2002) – training and outstanding work in European and American universities
Journal Title: Eminak - Year 2017, Vol 3, Issue 1
Abstract
In this article highlights the outstanding work of our countryman, biochemist Erwin Chargaff from Chernivtsi, in European and American universities. Analyzed every stage of this activity. Highlights E. Chargaff `s contribution to the development of nucleic acid chemistry. Transformation E. Chargaff to the biochemist largely is caused by that he had entered to a small group of biologists, who followed by the events in molecular biology and exchanged information each other. This allowed them to better understand the molecular processes by studying them under a new paradigm, which evolved and led to the synthesis of DNA. Chargaff made unique contribution by his own biochemical studies made in 1928-2000 in the traditions of different scientific schools. E. Chargaff was not American, until his last days heconsidered himself as a true European. In 1950-1953 he, studying quantitative correlation of nitrogenous bases in nucleic acids, showed that the common amount of adenine bases, each DNA molecule equal to the number thymine, and the number guanine basics - number of cytosine. This discovery, called «Chargaff rule» was used by F. Crick and J. Watson to construct a model of the DNA molecule. Chargaff thanks his research discovered of species specificity of DNA. He led the significant studying of protein synthesis proses, and the definition of DNA role in the transmission of hereditary information. Much attention scientist paid philosophical problems of science, reflected on the moral aspects of molecular genetic experiments, interested in socio-cultural component of the development of science in the twentieth century.
Authors and Affiliations
Oleg Pylypchuk
Keywords
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