Erythrocyte alloimmunization, rhesus and kell phenotypes for women of childbearing age in Yaounde
Journal Title: The Journal of Medical Research - Year 2018, Vol 4, Issue 1
Abstract
Erythrocyte alloimmunization has adverse consequences for polytransfused and obstetric for the fetus of an allo immune mother. However, it remains undervalued in our country. To give an estimate, from September to December 2016, we conducted a prospective study that included 157 women, including 54 transfused and 103 women who previously had a history of non-transfusion obstetrics. These patients were recruited from the maternity ward at Central Hospital in Yaounde. Irregular agglutinins (IA) were investigated at the Freelys Nano and tube stations using the indirect Coombs technique, blood grouping in the ABO system, and rhesus and Kell phenotypes were made on a plate by the agglutination technique at the Bethany laboratory. Regarding the incidence of irregular agglutinins in nontransfused women with an obstetrical history, 21% (22/103) were positive at RAI. Similarly, 33% (18/54) of the polytransfused multiparas were alloimmune. Similarly, 33% (18/54) of the polytransfused multipares were immunized. The most frequent antigenic combinations in the study population were D+C-E-c+e+ (60%), D+C+E-c+e+ (24%). D+C+ Ec+e+(0.61%), D+C-E+c+ (0.61%), D+C+E+c+e+ (1.8%) were rare. The most found antigens were: c (99%), e (99%), D (97%) and d (2%), K+ (1%) were rare. To reduce the risk of allo immunization in Cameroon phenotype at least in rhesus and Kell systems, the search for irregular agglutinins must be done routinely in transfusion therapy and in obstetrics. Transfusion of non-phenotyped blood should be formally prohibited in the general population; especially among women of reproductive age.
Authors and Affiliations
Ngo Sack Françoise, Tchongouang David, Chetcha C. Bernard, Essomba René
Keywords
Related Articles
- EP ID EP521888
- DOI 10.31254/jmr.2018.4106
- Views 104
- Downloads 0
Femoral hypoplasia- unusual facies syndrome: A case report and literature review
The femoral hypoplasia- unusual facies syndrome (FH/ UFS); also known as femoral facial syndrome (FFS), is a rare condition characterized by a variable degree of unilateral or bilateral femoral hypoplasia associated with...
Perceptions of clinical years’ medical students and interns about factors affecting their exam performance, King Abdulaziz University, Jeddahh
Background: The quality of medical students’ academic performance is an essential part of the success of the educational process. The current study was done to identify the perception of clinical years’ medical students...
Ranking of top authors of medical research of India: Quality Vs Quantity
In this study effort is made to analyse the ranking of two top most medical institutes of India. The data is extracted from ‘SCOPUS’ citation database for the period of five year i.e. 2013-2017. Initially, growth of publ...
Patient Safety in paediatrics and neonatal medication
Patient safety needs to be addressed for better health services. This needs a stringent uniform regulatory system. Although, after 2013 Central Drug Standard Control Organisation, CDSCO has laid down regulations for clin...
Laparoscopic peritoneal biopsy for the diagnosis of tuberculous peritonitis in a peritoneal dialysis patient
Peritoneal tuberculosis is a rare but a severe disease in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 60 years old male, who had been the CAPD program during the last 5 months, was admitted to...