Estimated Glomerular Filtration Rate (eGFR) in Healthy Kidney Donors
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Introduction: This study was done to determine the range of Glomerular filtration rate (GFR) in healthy kidney donors, from Kerala. Materials and Methods: This retrospective study was done by including all consecutive voluntary kidney donors, who underwent donor nephrectomy at Amrita Institute of Medical Sciences, Kochi, Kerala from 2001 to 2011. The GFR was assessed by 99mTc-diethylenetriamine pentaacetic acid (DTPA) renogram (GC Gates method) as part of protocol during preoperative evaluation. The GFR by DTPA method was compared to values obtained by four variable MDRD formula and Cockcroft-Gault formula (CGF). Results: The mean age of the study population was 45.32 years (Range - 18 to 64 years) with 71.7 % being females. The majority of the donors were parents (54.78%) followed by siblings (33.04%) and spouses (12.17%). The eGFR in a healthy kidney donor ranged was 56 to 117 ml/min by 99mTc DTPA; GC Gates method. The mean eGFR were 82.89 (SD:22.46), 85.25 (SD:16.90), and 84.56 (SD:11.60) ml/min by CGF, MDRD and DTPA respectively. There was positive correlation in eGFR between methods used in the study. In donors with DTPA GFR ranging from 80-100 ml/min; there was no significant difference in mean eGFR between methods. Conclusions: The mean eGFR of a kidney donor from India, was 84.56 (±11.60) ml/min, which is lower than the normal value of western population. In donors with DTPA GFR < 80 ml/min; MDRD and CGF methods overestimated GFR. In donors with DTPA GFR >100 ml/min; the CGF, MDRD methods underestimated the GFR.
Authors and Affiliations
Sheetal LG
Keywords
Related Articles
- EP ID EP213182
- DOI -
- Views 71
- Downloads 0
Tuberculosis –One of the Important Causes of Retroperitoneal Fibrosis in India
Introduction: Retroperitoneal fibrosis (RPF) is an uncommon condition in which a predominantly inflammatory plaque encasing the aorta, inferior vena cava, ureters, other retroperitoneal structures. A definitive etiology...
Evaluation of efficacy of gastrografin in adhesive small bowel obstruction
Background: Various conservative means of managing ASBO have been reported, including nasogastric tube suction and fluid resuscitation, and administration of water-soluble contrast agents, such as gastrografin, which may...
Role of Magnetic Resonace Imaging in Patients with Chronic Wrist Pain
Background: The wrist is a complex joint that bridges the hand to the forearm. Chronic wrist pain causes disabilities in day to day activities. Clinical examination helps in assessment, but for further evaluation, imagin...
Behavioural Pattern of Post-Mastectomy Patients Attending Radiotherapy Clinic At Ahmadu Bello University Teaching Hospital, Zaria
This study explored the pattern of some of the behaviours of post-mastectomy patients attending the radiotherapy clinic at the Ahmadu Bello University Teaching Hospital, Zaria and factors influencing some selected behavi...
A Rare Case of 12 Year Old Girl with Giant Fibroadenoma with Phylloides Tumour showing Features of Intraductal Papilloma
Breast tumours in prepubertal females are usually rare. Most commonly they present as adult type Fibroadenoma (FA).We reporta rare case of 12 year old girl who presented to our side with a painless progressive breast lum...