Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients
Journal Title: Journal of Diabetes and Obesity - Year 2018, Vol 5, Issue 1
Abstract
Introduction Abdominal visceral fat accumulation can cause insulin resistance in type 2 diabetic patients We investigated the association between serum fatty acid levels and the visceral fat area VFA Materials and methods In this retrospective study we evaluated relationship between the serum levels of 24 fatty acids and the abdominal VFA measured by computed tomography in 32 patients with type 2 diabetes who had been hospitalized Results Of the 24 fatty acids evaluated the serum palmitoleic acid C16 1 n-7 level had a moderate positive correlation r 0 565 with VFA while the serum arachidic acid C 20 0 level had a very weak negative correlation r -0 351 no significant correlations with the VFA were found for the remaining 22 fatty acids On the other hand we discovered 5 significant correlations in 18 estimated activity indices of elongases and desaturases which were calculated with ratios of corresponding fatty acid concentrations The palmitoleic acid C16 1 n-7 palmitic acid C16 0 r 0 719 stearoyl-CoA-desaturase SCD -1 16 index and the oleic acid C18 1 n-9 stearic acid C18 0 r 0 534 SCD-1 18 index had moderate to strong correlations with the VFA whereas stearic acid C18 0 palmitic acid C16 0 r - 0 495 elongase of very long chain Elovl 6 index exhibited a significant negative correlation Conclusions The serum palmitoleic acid C16 1 n-7 level and some estimated activity indices significantly correlated with the VFA in the type 2 diabetic patients SCD-1 indices and an Elovl6 index were reciprocally associated with the VFA The SCD-1 16 index which showed the strongest correlation with the VFA along with the negative association of the Elovl-6 index might be useful in estimating the VFA
Authors and Affiliations
SHIGERU YATOH
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- EP ID EP418293
- DOI 10.15436/2376-0494.18.1911
- Views 75
- Downloads 0
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