Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 3
Abstract
Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques. Material and Methods: In this applied research, fourteen children patients (6 males and 8 females) were imaged using a series of planar and SPECT images after injecting with technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA). A hybrid planar/SPECT method was used to plot time-activity curves to obtain the residence time of the source organs and also MIRDOSE software was used to calculate the absorbed dose of every organ. P-values were calculated using t-tests in order to make a comparison between the adsorbed doses of male and female groups. Results: Mean absorbed doses (µGy/MBq) for urinary bladder wall, kidneys, gonads, liver and adrenals were 213.5±47.8, 12.97±6.23, 12.0±2.5, 4.29±1.47, and 3.31±0.96, respectively. Furthermore, the mean effective dose was 17.5±3.7 µSv/ MBq. There was not any significant difference in the mean absorbed dose of the two groups. Conclusion: Bladder cumulated activity was the most contribution in the effective dose of patients scanned with 99mTc-DTPA. Using a hybrid planar/SPECT method can cause an increase in accumulated activity accuracy for the region of interest. Moreover, patient-specified internal dosimetry is recommended. Citation: Ebrahimnejad Gorji K, Abedi Firouzjah R, Khanzadeh F, Abdi-Goushbolagh N, Banaei A, Ataei Gh. Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software. J Biomed Phys Eng. 2019;9(3):285-294. https://doi.org/10.31661/jbpe.v0i0.984.
Authors and Affiliations
Gh. Ataei, K. Ebrahimnejad Gorji, R. Abedi Firouzjah, F. Khanzadeh, N. Abdi-Goushbolagh
Keywords
Related Articles
- EP ID EP613551
- DOI -
- Views 122
- Downloads 0
Detection of Ultraweak Photon Emission (UPE) from Cells as a Tool for Pathological Studies
Objective: It is well-known that all living cells emit ultra-weak photon emission (UPE), which is due to byproducts of chemical reactions in cell metabolisms. It has been shown that Reactive Oxygen Species (ROS) in the c...
A Glance at the Errors of Some Studies on the Health Effects of High Background Natural Radiation Areas
There is no place on the Earth, the planet we live on, where the natural background radiation level is zero. Since the birth and even in our fetal stage, we have been exposed to different sources of natural radiation. Li...
Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?
Since the early days of human life on the Earth, our skin has been exposed to different levels of light. Recently, due to inevitable consequences of modern life, humans are not exposed to adequate levels of natural light...
Smart Phone Acceptance among Physicians: Application of Structural Equation Modelling in the Largest Iranian University
Background: The present study aimed to determine attitudes and effective factors in the acceptance of smart phones by physicians of the largest University of Medical Sciences in the south of Iran. Methods: This cross-se...
Radioprotective Effects of Sulfur-containing Mineral Water of Ramsar Hot Spring with High Natural Background Radiation on Mouse Bone Marrow Cells
Background: We intend to study the inhibitory effect of sulfur compound in Ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. Objective: The radioprotective effect of sulfur compoun...