Estimation of an Efficient Antiemetic Agent for Prevention of Postoperative Nausea and Vomiting in Children Undergoing Tonsillectomy
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 1
Abstract
Postoperative nausea and vomiting (PONV) remains one of the commonest causes of significant morbidity after tonsillectomy in children. A variety of prophylactic antiemetic interventions have been reported, but there has only been a limited systematic review in this patient group. Aim: To find an efficient antiemetic agent for prevention of PONV in children undergoing tonsillectomy performed under G.A. Methods: We included 75 patients in the age group of 515 years undergoing Tonsillectomy. Patients were randomly divided into 3 groups of 25 patients each. The patients of Group I received Metoclopramide 0.25mg/kg, Group II Ondansetron 100 mcg/ kg and group III received Granisetron 40 mcg/kg intravenously just prior to induction of anesthesia. The following parameters were monitored during the study: Duration and quality of antiemesis, Pulse rate, Blood pressure, Modified Aldrete’s Score and Side effects if any. Results: Based on scoring system, it was found that the recovery score was 9. The patients were observed from 0–3 hrs and 324 hrs following Tonsillectomy for episodes of Nausea and / or Vomiting. Incidence of nausea and/or vomiting during 324 hrs after surgery is 44%, 20% and 8% in Groups I, II, and III respectively , with a statistically significant difference between Metoclopramide (Gr. I) and Granisetron (Gr. II ). Conclusion: Granisetron in a dose of 40 mcg/kg is more effective with very less side effects than Metoclopramide and Ondansetron in the long term prevention of PONV in the children undergoing tonsillectomy under GA.
Authors and Affiliations
Deepak Falgunan
Keywords
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- EP ID EP462220
- DOI 10.21088/ijaa.2349.8471.4117.5
- Views 160
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